Leslie P Miller, Age 555 Rockridge Ln, San Antonio, TX 78209

2012024, Sep 27, 2012

Mar 23, 2012

13/429143

Jennifer Joy SMITH - Seattle WA, US
John David AITCHISON - Seattle WA, US
Leslie Rae MILLER - Seattle WA, US

Institute For Systems Biology - Seattle WA

C40B 30/04
C12Q 1/02

506 9, 435 29

The invention provides a method to detect an abnormal condition or disease state by assessing a characteristic response pattern of responder cells to indicators contained in a biological fluid of a subject. A characteristic disease-associated pattern can be obtained by determining the response pattern of responder cells to that of bodily fluids or fractions thereof from subjects known to exhibit a particular abnormal condition optionally comparing said pattern to such pattern elicited by fluids or fractions from normal subjects and identifying elements that differ. The identified elements constitute a characteristic or differential pattern which can then be used to identify the presence or stage of a disease in a test subject.

5469787, Nov 28, 1995

Mar 15, 1994

8/213673

Michael R. Turner - Renton WA
Leslie L. Miller - Redmond WA

Heath Custom Press, Inc. - Renton WA

B41M 114

101211

A multi-color printing press having a single segmented impression cylinder with multiple, segmented blanket cylinders of equal diameter arranged about the periphery thereof. The segments of the impression cylinder and the blanket cylinders are equal in length and the number of segments on the impression cylinder is equal to the number of segments on the blanket cylinders multiplied by a whole number, plus one additional segment. Each blanket cylinder is provided with a plate cylinder of equal diameter which has the same number of segments. Color rolls provide each segment of the plate cylinder with a different color. Sheets to be printed are fed to the gripping means on the successive segments of the impression cylinder and delivery means removes sheets after printing. Each sheet is held on the impression cylinder for a number of revolutions equal to the number of segments on any one blanket cylinder.

2016037, Dec 22, 2016

Aug 30, 2016

15/252039

- Seattle WA, US
John David AITCHISON - Seattle WA, US
Leslie Rae MILLER - Seattle WA, US

Institute for Systems Biology - Seattle WA

G01N 33/50
C12Q 1/68

The invention provides a method to detect an abnormal condition or disease state by assessing a characteristic response pattern of responder cells to indicators contained in a biological fluid of a subject. A characteristic disease-associated pattern can be obtained by determining the response pattern of responder cells to that of bodily fluids or fractions thereof from subjects known to exhibit a particular abnormal condition optionally comparing said pattern to such pattern elicited by fluids or fractions from normal subjects and identifying elements that differ. The identified elements constitute a characteristic or differential pattern which can then be used to identify the presence or stage of a disease in a test subject.

2016026, Sep 15, 2016

Sep 25, 2014

15/025207

- Seattle WA, US
Samuel Anthony DANZIGER - Seattle WA, US
John David AITCHISON - Seattle WA, US
Leslie Rae MILLER - Seattle WA, US

Institute for Systems Biology - Seattle WA

C12Q 1/68

Methods to detect amyotrophic lateral sclerosis (ALS) or presymptomatic Alzheimer's disease (PSAD) using an indicator cell assay platform (iCAP) in a test subject are described. Specifically, the disclosure provides a method comprising contacting a biological fluid of said test subject with indicator cells and assessing said indicator cells for the level of expression of an exon of CKIgamma2 that encodes the C-terminal palmitoylated region of said CKIgamma2, to determine the probability that a test subject is afflicted with amyotrophic lateral sclerosis (ALS). Further disclosed are methods of using indicator cells that are pan neuronal populations of glutamatergic (and/or GABAergic) neurons to determine the probability of the presence of presymptomatic or symptomatic Alzheimer's disease (PSAD) in a test subject.