Linda L Walker, Age 65Maricopa, AZ

8211873, Jul 3, 2012

Aug 6, 2010

12/851637

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics, inc. - Chandler AZ

C07C 229/36
C07C 229/34
A61K 8/02
A61K 31/665
A61K 31/315
A61K 31/31
A61K 31/30
A61K 31/28

514100, 424400, 424401, 562440, 514494, 514497, 514499, 514505

This invention relates to certain chirally-correct mitoprotectant phosphorylated heterocyclic agents [formula (I)], which are useful for the treatment of dermatological disorders that include challenged skin from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction; age spots; acne, loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness; skin depigmentation, and combinations thereof;.

8212076, Jul 3, 2012

Apr 12, 2011

13/084709

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Covalence, Inc. - Chandler AZ

C07C 229/08
C07C 233/05
C07D 233/64
C07D 207/08

564153, 562450, 548533, 5483381

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;.

8227426, Jul 24, 2012

Nov 16, 2010

12/947314

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics Inc. - Chandler AZ

A01N 43/04
A61K 8/73

514 23, 424 7013

This invention relates to certain complexes of ascorbic acid and its derivatives with certain natural antioxidant and anti-inflammatory ketones for topical or oral application; said complexes having general chemical formula (I), its isomers, and salts thereof, including their optically active or racemic forms. This invention also relates to a method of treatment of skin condition, including dark skin, age spots, acne, inflammation, loss of cellular antioxidants, collagen loss with aging, loss of skin pliability, loss of skin suppleness, skin wrinkles, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, photo-damage, nutritional deficiency, and combinations thereof;.

8258343, Sep 4, 2012

Feb 15, 2012

13/396890

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics, Inc. - Chandler AZ

C07C 229/08
C07C 233/05
C07D 233/64
C07D 207/08

564153, 562450, 548533, 5483381

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;.

8293943, Oct 23, 2012

Feb 18, 2012

13/400047

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics, Inc. - Chandler AZ

C07C 229/08
C07C 233/05
C07D 233/64
C07D 207/08

564153, 562450, 548533, 5483381

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;.

8314070, Nov 20, 2012

Jan 28, 2011

13/015805

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics, Inc. - Chandler AZ

A61K 31/704
A61K 31/7048
A61K 31/352
C07H 7/04
C07H 7/06
C07D 311/22

514 23, 514456, 536 187, 536 552, 549401

This invention relates to certain Aloesin derivatives with natural amino acids, peptides, and amino sugars (formula I). The compounds of the present invention possess osmoprotective properties, which are suitable for topical or oral application to treat dermatological disorders including challenged skin from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof:.

8394851, Mar 12, 2013

Oct 1, 2012

13/632582

Shyam K Gupta - Scottsdale AZ, US
Linda Walker - Cardiff CA, US

Island Kinetics, Inc. - Chandler AZ

C07D 311/22
C07D 309/12
C07H 7/04

514460, 514 23, 536 187

The present invention discloses a method to inhibit a free radical, including a mitochondrial free radical, comprising administering to a subject in need thereof an effective amount of a composition comprising a compound of formula (I: a, b), an isomer, or a salt thereof:.