Inventors:
Margaret A. Shipp - Wellesley MA, US
Ricardo Aguiar - Chestnut Hill MA, US
Liqun Gu - Plainsboro NJ, US
Kunihiko Takeyama - Newton MA, US
Assignee:
Dana-Farber Cancer Institute - Boston MA
International Classification:
C12N 15/00
C12N 15/85
C12N 15/63
C07H 21/04
US Classification:
435 696, 4353201, 435325, 4352523, 43525411, 536 235, 536 245
Abstract:
The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.