Liqun L Gu62 Maidenhead Rd, Princeton, NJ 08540

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62 Maidenhead Rd, Princeton, NJ 08540

Lawrenceville, NJ

Plainsboro, NJ

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Us Patents

Lymphoma Associated Molecules And Uses Therefor

US Patent:
7112420, Sep 26, 2006
Filed:
Sep 19, 2001
Appl. No.:
09/957635
Inventors:
Margaret A. Shipp - Wellesley MA, US
Ricardo Aguiar - Chestnut Hill MA, US
Liqun Gu - Plainsboro NJ, US
Kunihiko Takeyama - Newton MA, US
Assignee:
Dana-Farber Cancer Institute - Boston MA
International Classification:
C12N 15/00
C12N 15/85
C12N 15/63
C07H 21/04
US Classification:
435 696, 4353201, 435325, 4352523, 43525411, 536 235, 536 245
Abstract:
The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.

Lymphoma Associated Molecules And Uses Therefor

US Patent:
2007025, Nov 8, 2007
Filed:
May 9, 2005
Appl. No.:
11/125015
Inventors:
Margaret Shipp - Wellesley MA, US
Ricardo Aguiar - Chestnut Hill MA, US
Liqun Gu - Plainsboro NJ, US
Kunihiko Takeyama - Newton MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
C12Q 1/68
C07H 21/04
C07K 14/00
C07K 16/18
G01N 33/53
C12N 15/00
C12N 5/06
C12P 1/04
US Classification:
435006000, 435320100, 435325000, 435375000, 435069100, 435007100, 530350000, 530387100, 536023100
Abstract:
The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.

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