Marc Caron resumes & CV records
Resumes
Marc Caron
Principal
Work:
Interior Solutions Oc
Principal
Principal
Marc G Caron, Age 78803 Pleasant Green Rd, Hillsborough, NC 27278
Marc Caron Phones & Addresses
803 Pleasant Green Rd, Hillsborough, NC 27278 (919) 309-0657
941 Happy Valley Farm Dr, Hillsborough, NC 27278
Hillsboro, NC
Durham, NC
Chapel Hill, NC
Cary, NC
Mentions for Marc G Caron
Publications & IP owners
Us Patents
Inhibition Of Arrestin Mediated Effects Prolongs And Potentiates Opioid Receptor-Mediated Analgesia
US Patent:
6528271, Mar 4, 2003
Filed:
Dec 22, 1999
Appl. No.:
09/469554
Inventors:
Laura M. Bohn - Durham NC
Marc G. Caron - Hillsborough NC
Robert J. Lefkowitz - Durham NC
Marc G. Caron - Hillsborough NC
Robert J. Lefkowitz - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C07K 1400
US Classification:
435 72, 435 4, 530350
Abstract:
The present invention provides a arrestin knockout mouse useful for screeening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of arrestin to phosphorylated opioid receptors, and methods of screening a compound for activity in potentiating opioid receptor agonist activity (e. g. , morphine activity) by determining whether or not said compound inhibits arrestin binding to a phosphorylated opioid receptor.
Method Of Detecting Inhibitors Of Agonist-Specific Desensitization
US Patent:
6605424, Aug 12, 2003
Filed:
May 11, 2000
Appl. No.:
09/568983
Inventors:
Robert J. Lefkowitz - Durham NC
Martin J. Lohse - Durham NC
Jeffrey L. Benovic - Durham NC
Marc G. Caron - Durham NC
Martin J. Lohse - Durham NC
Jeffrey L. Benovic - Durham NC
Marc G. Caron - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 300
US Classification:
435 4, 435 71, 435 35, 435183, 435194
Abstract:
The present invention relates to a method of inhibiting desensitization of a cell to the effects of a compound. The method comprises contacting the cell with an agent capable of inhibiting phosphorylation, by a protein kinase, of a receptor for the compound present on the surface of the cell. The present invention also relates to a method of screening a compound for its ability to inhibit desensitization. The method comprises: i) contacting a receptor specific kinase-containing sample with the compound under conditions such that interaction between receptor specific kinase present in the sample and the compound can occur, and ii) determining the ability of the receptor specific kinase to phosphorylate the receptor for which it is specific.
Methods Of Assaying Receptor Activity And Constructs Useful In Such Methods
US Patent:
6770449, Aug 3, 2004
Filed:
Jan 30, 2001
Appl. No.:
09/772644
Inventors:
Lawrence S. Barak - Durham NC
Marc G. Caron - Hillsborough NC
Stephen S. Ferguson - London, CA
Jie Zhang - Durham NC
Marc G. Caron - Hillsborough NC
Stephen S. Ferguson - London, CA
Jie Zhang - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
G01N 33567
US Classification:
435 72, 435 4, 435 71, 435325, 530350
Abstract:
Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.
Expression Of G Protein Coupled Receptors In Yeast
US Patent:
6855550, Feb 15, 2005
Filed:
Dec 29, 2000
Appl. No.:
09/752145
Inventors:
Klim King - Durham NC, US
Henrik G. Dohlman - Berkeley CA, US
Marc G. Caron - Durham NC, US
Robert J. Lefkowitz - Durham NC, US
Henrik G. Dohlman - Berkeley CA, US
Marc G. Caron - Durham NC, US
Robert J. Lefkowitz - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
C12N015/81
C12P021/04
G01N033/569
C12P021/04
G01N033/569
US Classification:
435483, 435 731, 435 699
Abstract:
Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protean coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian G). The first and second heterologous DNA sequences are capable of expression in the cell, but the cell is incapable of expressing an endogenous G protein α-subunit (yeast G). The cells are useful for screening compounds which affect the rate of dissociation of G from G in a cell. Also disclosed is a novel DNA expression vector useful for making cells as described above. The vector contains a first segment comprising at least a fragment of the extreme amino-terminal coding sequence of a yeast G protein coupled receptor. A second segment is positioned downstream from the first segment (and in correct reading frame therewith), with the second segment comprising a DNA sequence encoding a heterologous G protein coupled receptor.
Modified G-Protein Coupled Receptors
US Patent:
7018812, Mar 28, 2006
Filed:
Nov 5, 2001
Appl. No.:
09/993844
Inventors:
Robert H. Oakley - Durham NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Assignee:
Duke University - Durham NC
International Classification:
C07K 14/705
C07K 19/00
C12N 15/62
C07K 19/00
C12N 15/62
US Classification:
435 697, 4352523, 4353201, 530350, 536 234
Abstract:
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
Methods Of Assaying Receptor Activity
US Patent:
7138240, Nov 21, 2006
Filed:
May 9, 2002
Appl. No.:
10/141725
Inventors:
Lawrence S. Barak - Durham NC, US
Marc G. Caron - Hillsborough NC, US
Stephen S. Ferguson - London, CA
Jie Zhang - Durham NC, US
Marc G. Caron - Hillsborough NC, US
Stephen S. Ferguson - London, CA
Jie Zhang - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
G01N 33/566
G01N 21/76
G01N 33/53
G01N 21/76
G01N 33/53
US Classification:
435 71, 435 73, 4352887, 436172, 436 42, 436501
Abstract:
Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process.
Methods Of Screening Compositions For G Protein-Coupled Receptor Desensitization Inhibitory Activity
US Patent:
7163800, Jan 16, 2007
Filed:
Aug 1, 2003
Appl. No.:
10/633438
Inventors:
Robert H. Oakley - Durham NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Assignee:
Molecular Devices Corporation - Sunnyvale CA
International Classification:
G01N 33/566
US Classification:
435 721, 435 71, 435 72, 436501
Abstract:
The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs that are different from each other. When there is an indication that a particular test composition has GPCR desensitization inhibitory activity with respect to each of the two or more GPCRs that are different from one another, then, according to the present invention, there is an indication that the test composition has non-receptor-specific GPCR desensitization inhibitory activity.
Modified G-Protein Coupled Receptors
US Patent:
7214496, May 8, 2007
Filed:
Dec 30, 2004
Appl. No.:
11/026435
Inventors:
Robert H. Oakley - Durham NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Lawrence S. Barak - Durham NC, US
Stephane A. Laporte - Outremont, CA
Marc G. Caron - Hillsborough NC, US
Assignee:
Duke University - Durham NC
International Classification:
G01N 33/53
US Classification:
435 71, 435 721, 435 697, 4352523, 436501
Abstract:
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
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