Margaret J Gentles, Age 9668 Day St, Bloomfield, NJ 07003

5412104, May 2, 1995

Mar 1, 1993

8/030186

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

A61K 3147

548525

Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1. 0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1. 0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1. 0 wherein R is selected from the group consisting of H, halogen and --C(O)OR. sup. 6 ; and R. sup. 1 is selected from the group consisting of --OR. sup. 14, --O(CH. sub. 2). sub. a C(H). sub. 3-i Z. sub. i and --O(CH. sub. 2). sub. h N(R. sup. 15). sub. 2.

5382572, Jan 17, 1995

Mar 1, 1993

8/030187

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

C07D21522
A61K 3137

514 82

Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1. 0: ##STR1## and their pharmaceutically acceptable salts and solvates; wherein: (A) X is selected from the group consisting of N--R. sup. 3, O, S, and C(R. sup. 3). sub. 2 ; (B) R. sup. 3 is selected from H and a range of substituents; (C) R. sup. 1 is an etherifying or esterifying group; (D) R. sup. 2 is selected from a range of substituents; (E) m is 0 or an integer from 1 to 4; and (F) R. sup. 4 and R. sup. 5 are the same and are selected from alkyl and acyl groups; together with the pharmaceutically acceptable salts of the compounds of Formula 1. 0 that are acidic or basic. Pharmaceutical compositions containing compounds represented by Formula 1.

5190956, Mar 2, 1993

Sep 7, 1990

7/579919

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

C07D21520
C07D21522
A61K 3147

514312

Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 00 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1. 00 The compounds of Formula 1. 00 are also useful as intermediates to compounds of: ##STR2## Compounds of Formula 1. 0 are useful as antiviral agents against the same viruses that the compounds of Formula 1. 00 are useful against.

5378694, Jan 3, 1995

Mar 1, 1993

7/983519

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ
Stuart B. Rosenblum - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D21556
A61K 3147

514 82

Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1. 0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 0 and methods of treating a viral infection using compounds represented by Formula 1. 0 are disclosed. Also disclosed are compounds useful as antihypertensive agents and methods of treating hypertension using such compounds. The antihypertensive agents are compounds represented by Formula 1. 0 wherein R. sup. 4 is selected from the group consisting of alkyl and aminoalkyl. Preferably R. sup. 1 is H.

5942522, Aug 24, 1999

Feb 26, 1997

8/806585

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret Jevnik Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

A61K 3137
C07D21522

514312

Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1. 0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1. 0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1. 0 wherein R is selected from the group consisting of H, halogen and --C(O)OR. sup. 6 ; and R. sup. 1 is selected from the group consisting of --OR. sup. 14, --O(CH. sub. 2). sub. a C(H). sub. 3-i Z. sub. i and --O(CH. sub. 2). sub. h N(R. sup. 15). sub. 2.

5175151, Dec 29, 1992

Feb 5, 1992

7/830958

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

C07D21556

514 63

Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1. 0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 0 are disclosed. Also disclosed are methods of treating hypertension or a viral infection using compounds represented by Formulas 1. Also disclosed is a compound of Structure B ##STR2## useful as an intermediate in producing compounds of Formula 1. A process for preparing the compounds of Formula 1. 0 is also disclosed. In the process a compound of Structure B ##STR3## is reacted with an alkoxide R. sub. 1 O. sup. - M. sup. + in a solvent comprising the corresponding alcohol R. sub. 1 OH of the alkoxide.

4076708, Feb 28, 1978

Dec 22, 1976

5/753257

Michael J. Green - Kendall Park NJ
Elliot L. Shapiro - Cedar Grove NJ
Margaret A. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

C07J 7100

26023957

3-Oxo-6-unsubstituted-7. alpha. -halogeno-4-dehydro steroids, wherein said halogen is chlorine, bromine or iodine, are prepared by reaction of a 3-oxo-6,7-di-unsubstituted-4,6-bis-dehydro steroid with at least an equimolar quantity of the corresponding hydrogen halide in a non-reactive organic solvent at temperatures no higher than about 30. degree. C, and then are isolated by removal of said solvent and any excess acid at temperatures no higher than about 25. degree. C without subjecting said 3-oxo-6-unsubstituted-7. alpha. -halogeno-4-dehydro steroid to a basic medium. A preferred species of this process is that wherein the starting steroid is a 3,20-dioxo-9-unsubstituted-11-oxygenated-1,4,6-pregnatriene-17,21-diol or ester thereof, preferably a 17,21-di-lower alkanoate or a 17-benzoate 21-lower alkanoate ester thereof, whereby is prepared in good yields a 3,20-dioxo-7. alpha. -halogeno-1,4-pregnadiene-17. alpha. ,21-diol or ester thereof, useful as topical anti-inflammatory agents.

5179107, Jan 12, 1993

Dec 19, 1991

7/811890

Adriano Afonso - West Caldwell NJ
Jay Weinstein - Upper Montclair NJ
Margaret J. Gentles - Bloomfield NJ

Schering Corporation - Kenilworth NJ

C07D21522
A61K 3147
A01N 4342

514312

Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1. 0 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1. A process for making compounds of Formula 1. 0 from the appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2. 5) is also disclosed. The process comprises reductively hydrolyzing an appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2. 5) in a mixture with a hydrogenation catalyst and an acidic solvent mixture.