Margaret W Mcnerney, Age 444750 Tassajara Rd UNIT 5223, Dublin, CA 94568

2015005, Feb 19, 2015

Aug 5, 2014

14/452453

- Livermore CA, US
Margaret Windy Mcnerney - Pleasanton CA, US
Satinderpall S. Pannu - Pleasanton CA, US
Elizabeth K. Wheeler - Livermore CA, US

G01N 33/50

435 29, 435397

A tissue system includes: a support material; and a vascular network comprising a plurality of channels disposed in the support material. A method includes printing a bioink in a support structure to form a network of vascular precursor materials; and converting the vascular precursor materials into a physiologically relevant vascular network. Notably, the tissue systems, networks, etc. are physiologically-relevant, i.e. exhibiting one or more characteristics indicative of physiological relevance, such as a substantially fractal geometry, inter-vessel spacing, cellular composition, dermal structure, concentric multi-layered structure, etc.

2014032, Oct 30, 2014

Apr 29, 2014

14/265019

- Livermore CA, US
Haiyin Chen - San Ramon CA, US
Bryan D. Hudson - Livermore CA, US
Kris Kulp - Livermore CA, US
Margaret W. Mcnerney - Pleasanton CA, US
Satinderpall S. Pannu - Pleasanton CA, US
Fang Qian - Santa Cruz CA, US
Angela C. Tooker - Dublin CA, US
Elizabeth K. Wheeler - Livermore CA, US

Lawrence Livermore National Security, LLC - Livermore CA

C12M 3/06
C12M 3/00

435 5, 4352891, 4352872, 4352879, 4353031, 435325, 435 29, 435 61

In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a, plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.