Mark J Alderson, Age 603120 Rockefeller Ave UNIT 9, Everett, WA 98201

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2610 Hoyt Ave, Everett, WA 98201

2615 Rucker Ave, Everett, WA 98201 (425) 512-0402

Snohomish, WA

Westfield, MA

Seattle, WA

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Us Patents

Cytokine Designated 4-1Bb Ligand Antibodies And Human Receptor That Binds Thereto

US Patent:
6355779, Mar 12, 2002
Filed:
Sep 10, 1998
Appl. No.:
09/150864
Inventors:
Raymond G. Goodwin - Seattle WA
Craig A. Smith - Seattle WA
Mark R. Alderson - Bainbridge Island WA
Assignee:
Immunex Corporation - Seattle WA
International Classification:
C07K 1600
US Classification:
53038823, 53038822, 530350, 530351, 435 691, 436501, 536 235, 536 2431
Abstract:
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses

US Patent:
6544522, Apr 8, 2003
Filed:
Dec 30, 1998
Appl. No.:
09/223040
Inventors:
Yasir Skeiky - Seattle WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K 3902
US Classification:
4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237
Abstract:
The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

Compounds For Diagnosis Of Tuberculosis And Methods For Their Use

US Patent:
6555653, Apr 29, 2003
Filed:
May 5, 1998
Appl. No.:
09/073009
Inventors:
Mark Raymond Alderson - Bainbridge Island WA
Davin C. Dillon - Redmond WA
Yasir A. W. Skeiky - Seattle WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:
Corixa Corporation - Seattle WA
International Classification:
C07K 100
US Classification:
530350, 4242481, 4241841, 4242341, 4241921, 4241681, 536 231
Abstract:
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Compounds For Immunotherapy And Diagnosis Of Tuberculosis And Methods Of Their Use

US Patent:
6613881, Sep 2, 2003
Filed:
May 5, 1998
Appl. No.:
09/073010
Inventors:
Mark Raymond Alderson - Bainbridge Island WA
Davin C. Dillon - Redmond WA
Yasir A. W. Skeiky - Seattle WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:
Corixa Corporation - Seattle WA
International Classification:
C07K 100
US Classification:
530350, 536 231, 435 6
Abstract:
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against infection, or may be used for the diagnosis of tuberculosis.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses

US Patent:
6627198, Sep 30, 2003
Filed:
Apr 7, 1999
Appl. No.:
09/287849
Inventors:
Steven G. Reed - Bellevue WA
Yasir A. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K 3902
US Classification:
4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237
Abstract:
The present invention relates to fusion proteins containing at least two antigens. In particular, it relates to bi-fusion proteins which contain two individual antigens, tri-fusion proteins which contain three antigens, tetra-fusion proteins which contain four antigens, and penta-fusion proteins which contain five antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses

US Patent:
7064195, Jun 20, 2006
Filed:
Feb 5, 2003
Appl. No.:
10/359459
Inventors:
Yasir Skeiky - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US
Antonio Campos-Neto - Bainbridge Island WA, US
Assignee:
Corixa - Seattle WA
International Classification:
C07H 21/04
C07H 21/02
A61K 39/04
US Classification:
536 237, 424 92, 4241301, 4241641, 4241681, 4241901, 4242481, 435 691, 435 693, 514 44, 530350, 536 231
Abstract:
The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

Fusion Proteins Of

US Patent:
7083796, Aug 1, 2006
Filed:
Jun 20, 2001
Appl. No.:
09/886349
Inventors:
Yasir Skeiky - Seattle WA, US
Steven Reed - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K 39/04
A61K 49/00
A61K 45/00
US Classification:
4242481, 424 91, 424 92, 4241841, 4241851, 4241901, 4241921, 4242341, 4242781, 530300, 530350
Abstract:
The present invention relates to compositions and fusion proteins containing at least two sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Antibodies To Human 4-1Bb

US Patent:
7138500, Nov 21, 2006
Filed:
Sep 10, 1998
Appl. No.:
09/151259
Inventors:
Raymond G. Goodwin - Seattle WA, US
Craig A. Smith - Seattle WA, US
Mark R. Alderson - Bainbridge Island WA, US
Assignee:
Immunex Corporation - Thousand Oaks CA
International Classification:
A61K 39/395
C12P 21/08
G01N 33/567
C07H 21/04
C07K 14/52
US Classification:
53038822, 530350, 530351, 435 721, 435 691, 435 695, 435326, 435335, 4241301, 4241431, 436501, 536 231
Abstract:
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

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