Mark E Burkard, Age 527896 Serene Ct, Cross Plains, WI 53528

5869538, Feb 9, 1999

Nov 26, 1996

8/753581

Hugh D. Van Liew - West Amherst NY
Mark E. Burkard - Rochester NY
Clas E. G. Lundgren - Snyder NY
Ingvald M. Tyssebotn - Buffalo NY

Research Foundation of State University of New York - Amherst NY

A61K 3102
A61K 31035
A61K 3103

514743

Disclosed are methods of using stabilized microbubbles, such as those formulated from slowly permeating gas, to deliver or remove from tissue at least one gas selected from a respiratory gas, anesthetic gas, inert gas, or toxic gas. The methods comprise introducing, into the blood circulation of an individual to be treated, a therapeutically effective amount of the stabilized microbubbles. The methods are based on using the inherent physical properties of the blood circulation, of the microbubbles, and of the gases. The methods are especially useful for enhancing transport of oxygen in applications or conditions such as blood loss, anemia, organ perfusion, coronary Angioplasty, venous to arterial shunting of blood, oxygenation of ischemic tissues resulting from vascular obstructions, and oxygenation of solid tumor tissues in anticancer therapy.

6127428, Oct 3, 2000

Feb 8, 1999

9/246239

Clas E. G. Lundgren - Synder NY
Ingvald M. Tyssebotn - Buffalo NY
Hugh D. Van Liew - Barnstable MA
Mark E. Burkard - Rochester NY

The Research Foundation of State University of New York - Amherst NY

A61K 3102
A61K 31035

514743

A method is disclosed for the treatment of right to left shunt. The method comprises introducing, into the blood circulation of an individual, to be treated, a therapeutically effective amount of the stabilized microbubbles. In a preferred embodiment, oxygen is additionally administered to the individual.

2020015, May 21, 2020

Nov 14, 2019

16/684191

- Madison WI, US
Mark E. Burkard - Cross Plains WI, US

C12N 15/10
C12N 15/85
C12N 9/22
C12N 15/11

Constructs, vectors, and methods for enhancing homology directed repair using the CRISPR/Cas9 gene editing platform are disclosed.

2016034, Dec 1, 2016

Jun 1, 2015

14/727399

- Madison WI, US
Mark E. Burkard - Cross Plains WI, US
Jay W. Warrick - Madison WI, US
David J. Guckenberger - Oconomowoc WI, US
Lee G. Wilke - Madison WI, US

A61M 31/00

A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.