Inventors:
James A. Sikorski - Des Peres MO
Richard C. Durley - Chesterfield MO
Deborah A. Mischke - Defiance MO
Emily J. Reinhard - Chesterfield MO
Yvette M. Fobian - Labadie MO
Michael B. Tollefson - OFallon MO
Lijuan Wang - Wildwood MO
Margaret L. Grapperhaus - Troy IL
Brian S. Hickory - Wildwood MO
Mark A. Massa - Ballwin MO
Monica B. Norton - St. Louis MO
William F. Vernier - St. Louis MO
Barry L. Parnas - University City MO
Michele A. Promo - Chesterfield MO
Ashton T. Hamme - St. Louis MO
Dale P. Spangler - Deerfield IL
Melvin L. Rueppel - St. Louis MO
Assignee:
G.D. Searle Co. - Chicago IL
International Classification:
A61K 31426
US Classification:
514311, 514241, 514242, 514256, 514277, 514357, 514365, 514400, 514406, 514415, 514427, 514438, 514471, 514245, 514275, 514313, 514352, 514370, 514377, 514380, 514398, 514407, 514426, 514447, 514472, 544182, 544215, 544242, 544335, 544374, 544378, 544194, 544213, 544326, 544336, 544332, 546176, 546329, 546334, 546159, 546304, 546306, 548205, 548214, 548235, 5483355, 5483401, 5483751, 5483761, 548491, 548561, 548562, 548193, 548198, 548233, 5483311, 5483717, 5483725, 548483, 548557, 549 74, 549 78, 549491, 549497
Abstract:
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-phenyl-N-heteroaralkyl aminoalcohols. A preferred specific N-phenyl-N-heteroaralkyl aminoalcohol is the compound:.