Matthew J Carson, Age 52560 7Th Ave UNIT 3A, Brooklyn, NY 11215

4599336, Jul 8, 1986

Aug 8, 1983

6/521308

Matthew Carson - Nutley NJ
Ronald A. Le Mahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ
Jefferson W. Tilley - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31505
C07D40112

514259

Compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C. sub. 1 -C. sub. 7) alkyl-N(CH. sub. 2). sub. n O-- or 2-hydroxyethoxy; n is 2 to 7; R. sub. 2 is hydrogen, lower alkyl or lower alkoxy; R. sub. 3 is hydrogen or methyl; R. sub. 4 is hydrogen or lower alkyl; R. sub. 5 is hydrogen or lower alkyl provided however if R. sub. 2 is other than hydrogen R. sub. 5 is hydrogen; m is 1 to 7; Y is ##STR2## --O-- or --S--; w is zero or one; and A is an unsubstituted or substituted aromatic 5- or 6-membered heterocyclic radical; or pharmaceutically acceptable addition salts thereof are described. The compounds of formula I are useful for treating allergic conditions and vascular disorders.

4672066, Jun 9, 1987

Apr 22, 1985

6/725602

Matthew Carson - Nutley NJ
Ru-Jen L. Han - Princeton Junction NJ
Ronald A. LeMahieu - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D23926
C07D21355
C07D207327
A61K 3144

514256

The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Y is alkylene; Z is alkylene, ##STR2## the asterisk herein denotes bonding to the substituted acetophenone; R. sub. 2 is hydrogen or lower alkoxy; and n is an integer of 1 to 3; A is ##STR3## and HET is a 5-or 6- membered nitrogen containing heterocyclic group, and their acid addition salts. The compounds of formula I of the invention are useful for the treatment of allergic conditions, such as, asthma and cardiovascular diseases, such as, angina and arrhythmias.

5025036, Jun 18, 1991

May 3, 1989

7/347109

Matthew Carson - Nutley NJ
Ru-Jen L. Han - Princeton Junction NJ
Ronald A. LeMahieu - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 3119

514568

The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R. sub. 1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R. sub. 2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH. sub. 2). sub. n --N--(lower alkyl). sub. 2, R. sub. 3 is hydrogen, lower alkyl or amino, R. sub. 4 is hydrogen, lower alkyl, halogen or amino A is ##STR4## wherein, R. sub. 5 is hydrogen or acyl, R. sub. 6 is hydrogen, halogen, lower alkyl, aryl or cycloalkyl, and R. sub. 7 and R. sub. 8, independently, are hydrogen, lower alkyl or halogen, or A is ##STR5## wherein, R. sub. 5 is hydrogen or acyl, R. sub. 9 is hydrogen, lower alkyl, R. sub. 10 is hydrogen, lower alkyl or halogen, R. sub.

4663332, May 5, 1987

Oct 10, 1985

6/786386

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ

Hoffman-La Roche Inc. - Nutley NJ

C07D40106
A61K 3144

514340

Compounds of the formula ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3, and A are as described herein, are set forth. These compounds are useful as anti-allergic agents and agents for the treatment of cardiovascular diseases.

4628115, Dec 9, 1986

Mar 25, 1985

6/715440

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07L 5976

562464

The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Z is alkylene of 1 to 10 carbon atoms, --(C*H. sub. 2). sub. 3 --C. tbd. C--, --C*H. sub. 2 --C. tbd. C--(CH. sub. 2). sub. 3 --, and --(CH. sub. 2). sub. 2 O]. sub. n (CH. sub. 2). sub. 2 -- wherein n is an integer of 1 to 3, the carbon atom marked with an asterisk is linked to the phenoxy moiety, and salts thereof with pharmaceutically acceptable bases. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A; leukotrienes C. sub. 4, D. sub. 4 and E. sub. 4), which renders them useful as agents for the treatment of allergic conditions.

4782176, Nov 1, 1988

May 23, 1983

6/497375

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6976

560 53

Phenoxycarboxylic acids of the formula ##STR1## wherein R, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 R. sub. 5, Z and n are as hereinafter set forth, are as described. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A), which renders them useful as agents for the treatment of allergic conditions.

5191108, Mar 2, 1993

Apr 3, 1991

7/679962

Matthew Carson - Nutley NJ
Ru-Jen L. Han - Princeton Junction NJ
Ronald A. Lemahieu - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6976
C07C 4976

560 64

The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R. sub. 1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R. sub. 2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH. sub. 2). sub. n --N--(lower alkyl). sub. 2, R. sub. 3 is hydrogen, lower alkyl or amino, R. sub. 4 is hydrogen, lower alkyl, halogen or amino A is ##STR4## wherein, R. sub. 5 is hydrogen or acyl, R. sub. 6 is hydrogen, halogen, lower alkyl, aryl or cycloalky, and R. sub. 7 and R. sub. 8, independently, are hydrogen, lower alkyl or halogen, or A is ##STR5## wherein, R. sub. 5 is hydrogen or acyl, R. sub. 9 is hydrogen, lower alkyl, R. sub. 10 is hydrogen, lower alkyl or halogen, R. sub.

4507498, Mar 26, 1985

Jan 24, 1983

6/460719

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6976
C07C 6540

562463

Phenoxycarboxylic acids of the formula ##STR1## wherein R, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, Z and n are as hereinafter set forth, are as described. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A), which renders them useful as agents for the treatment of allergic conditions.