Inventors:
Loren D. Walensky - Newton Centre MA, US
Michelle L. Stewart - Brookline MA, US
Nicole Cohen - Newton MA, US
International Classification:
A61K 31/7034
C07D 311/30
A61K 31/352
A61P 35/00
C07C 255/42
A61K 31/26
C07D 407/04
A61K 31/351
C07J 43/00
A61K 31/58
C07D 493/04
A61K 31/366
C07C 321/30
A61K 31/10
C07C 39/16
A61K 31/055
C07H 15/203
C07D 405/14
A61K 31/498
A61K 31/53
C07D 409/12
A61K 31/5415
C07D 279/06
A61K 31/54
C07D 409/14
A61K 31/55
C12N 5/071
US Classification:
514 35, 435375, 549400, 514456, 558401, 514514, 549313, 514460, 540106, 514176, 549278, 514453, 568 48, 514712, 568726, 514735, 536 182, 544353, 514249, 544182, 514242, 544 39, 5142258, 544 54, 5142272, 540603, 5142171
Abstract:
This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.