Paul Torrence resumes & CV records
Resumes
Paul F Torrence, Age 811255 Stiles Rd, Woodhull, NY 14898
Paul Torrence Phones & Addresses
1255 Stiles Rd, Woodhull, NY 14898 (607) 525-6488
Anchor Bay, CA
Flagstaff, AZ
Ashland, OR
Williams, OR
Silver Spring, MD
Joseph, OR
Gaithersburg, MD
1255 Stiles Rd, Woodhull, NY 14898 (301) 417-0581
Social networks
Paul F Torrence
Linkedin
Work
Position:
Construction and Extraction Occupations
Education
Degree:
Bachelor's degree or higher
Mentions for Paul F Torrence
Publications & IP owners
Us Patents
Rnase L Activator-Antisense Complexes
US Patent:
2003020, Oct 30, 2003
Filed:
Jan 22, 2003
Appl. No.:
10/349163
Inventors:
Robert Silverman - Beachwood OH, US
Hagen Cramer - Cleveland Heights OH, US
Douglas Leaman - Whitehouse OH, US
Paul Torrence - Flagstaff AZ, US
Hagen Cramer - Cleveland Heights OH, US
Douglas Leaman - Whitehouse OH, US
Paul Torrence - Flagstaff AZ, US
Assignee:
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
A61K048/00
C07H021/02
C12Q001/70
C07H021/02
C12Q001/70
US Classification:
435/005000, 536/023720, 514/044000
Abstract:
The present invention relates to methods of targeting RNA and is particularly useful for inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome, antigenome or mRNAs of a target RNA (e.g. a negative strand RNA virus) to specifically cleave the genomic or antigenomic RNA strand of the target RNA (e.g. the virus). The invention in one embodiment relates to a covalently linked complex of an oligonucleotide that is capable of binding to the genomic or antigenomic template RNA strand of a negative strand RNA virus and/or binding to an mRNA of a viral protein (an “antisense oligonucleotide”) coupled to an activator of RNase L. In a preferred embodiment of the present invention, the oligonucleotide component of the complex is complementary to a region of the viral genomic RNA strand characterized by repeated or consensus sequences.
Chimeric Molecules Targeted To Viral Rnas
US Patent:
6271369, Aug 7, 2001
Filed:
Oct 14, 1997
Appl. No.:
8/950196
Inventors:
Paul F. Torrence - Flagstaff AZ
Robert H. Silverman - Beechwood OH
Ratan K. Maitra - South Euclid OH
Krystyna Lesiak - Stone Mountain GA
Robert H. Silverman - Beechwood OH
Ratan K. Maitra - South Euclid OH
Krystyna Lesiak - Stone Mountain GA
Assignee:
The United States of America as represented by the Department of Health and
Human Services - Washington DC
The Cleveland Clinic Foundation - Cleveland OH
Human Services - Washington DC
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
C07H 2102
C07H 2104
C12Q 168
C07H 2104
C12Q 168
US Classification:
536 245
Abstract:
Chimeric molecules comprising a virus targeting antisense oligonucleotide moiety attached to an activator of 2-5A-dependent RNase.
Isbn (Books And Publications)
Biological Response Modifiers: New Approaches For Disease Intervention
Author:
Paul F. Torrence
ISBN #:
0126957703
Biological Response Modifiers
Author:
Paul F. Torrence
ISBN #:
0126957711
Combating The Threat Of Pandemic Influenza: Drug Discovery Approaches
Author:
Paul F. Torrence
ISBN #:
0470118792
Combating The Threat Of Avian Influenza: Drug Discovery Approaches
Author:
Paul F. Torrence
ISBN #:
0470179724
Antiviral Drug Discovery For Emerging Diseases And Bioterrorism Threats
Author:
Paul F. Torrence
ISBN #:
0471668273
Antiviral Drug Discovery For Emerging Diseases And Bioterrorism Threats
Author:
Paul F. Torrence
ISBN #:
0471716707
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