Paulo S Garcia, Age 68Gloucester, MA

2020033, Oct 22, 2020

Jul 6, 2020

16/921824

- Cambridge MA, US
Paulo Andres Garcia Dominguez - Cambridge MA, US
Zhifei Ge - Cambridge MA, US
Jeffrey Lawrence Moran - Boston MA, US

C12N 13/00
C12M 3/06
C12M 1/42
C12M 1/26
B01L 3/00

An electroporation device with a volume of varying cross-sectional area that be used as a fast assay device for determining the optimal conditions for plasma membrane electroporation.

2020032, Oct 15, 2020

May 4, 2020

16/865772

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
Rafael V. Davalos - Blacksburg VA, US
Peter Callas - Castro Valley CA, US

A61B 18/00
A61B 18/14

The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.

2020009, Mar 26, 2020

Jul 24, 2015

14/808679

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
Rafael V. Davalos - Blacksburg VA, US
John H. Rossmeisl - Blacksburg VA, US
John L. Robertson - Floyd VA, US

A61B 19/00
A61N 1/04
A61B 18/12

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

2019025, Aug 22, 2019

May 6, 2019

16/404392

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
Rafael V. Davalos - Blacksburg VA, US
John H. Rossmeisl - Blacksburg VA, US
John L. Robertson - Floyd VA, US

C12N 13/00
A61B 34/10

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

2019023, Aug 1, 2019

Apr 5, 2019

16/375878

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
Rafael V. Davalos - Blacksburg VA, US
John H. Rossmeisl - Blacksburg VA, US
John L. Robertson - Floyd VA, US

C12N 13/00
A61B 34/10

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

2019017, Jun 13, 2019

Feb 14, 2019

16/275429

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
John L. Robertson - Floyd VA, US
John H. Rossmeisl - Blacksburg VA, US

A61B 18/14
A61B 18/12
A61N 1/32
C12N 13/00

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.

2017021, Aug 3, 2017

Dec 10, 2014

15/320696

- Cambridge MA, US
Paulo Andres Garcia Dominguez - Cambridge MA, US
Zhifei Ge - Cambridge MA, US
Jeffrey Lawrence Moran - Boston MA, US

C12N 13/00
C12M 3/06
B01L 3/00
C12M 1/42

An electroporation device with a volume of varying cross sectional area that as a fast assay device for determining the optimal conditions for plasma membrane electroporation.

2015016, Jun 18, 2015

Feb 20, 2015

14/627046

- Blacksburg VA, US
Paulo A. Garcia - Cambridge MA, US
John L. Robertson - Floyd VA, US
John H. Rossmeisl - Blacksburg VA, US

A61B 18/14
A61B 18/12

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.