Peter Lipke resumes & CV records
Resumes
Peter H Lipke, Age 78620 Stratford Ln, The Villages, FL 32162
Peter Lipke Phones & Addresses
620 Stratford Ln, The Villages, FL 32162
4415 Village Oaks Way, Atlanta, GA 30338 (770) 458-4502
Dunwoody, GA
4204 Ancient Amber Way, Norcross, GA 30092 (770) 864-5621
Peachtree Corners, GA
New York, NY
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Peter H Lipke
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Publications & IP owners
Us Patents
Screening Methods For Identifying Target Antifungal Genes And Compounds By Detecting Cell Surface Glycoproteins
US Patent:
2011004, Feb 24, 2011
Filed:
Feb 10, 2009
Appl. No.:
12/867113
Inventors:
Peter Lipke - Brooklyn NY, US
Marlyn Gonzalez - Forest Hills NY, US
Marlyn Gonzalez - Forest Hills NY, US
Assignee:
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK - New York NY
International Classification:
C12Q 1/68
G01N 33/53
G01N 33/53
US Classification:
435 6, 435 71
Abstract:
The present invention relates to an assay method that can be used for high-throughput detection of cell surface glycoproteins. Specifically, the secretion of a chimeric glycoprotein reporter signals disruption of GPI anchor-mediated attachment of the glycoprotein to the cell surface. This method provides a high signal-to-noise ratio and is particularly useful for screening compounds that affect GP1 anchor biosynthesis. The method of the present invention thus permits genome-wide screens for genes that are needed for GPI anchor-mediated attachment of a glycoprotein to the surface of a cell as well as chemical inhibitors of proteins that promote GP1 anchor-mediated attachment of a glycoprotein to the surface of a cell. Protein inhibitors identified by the present method could be useful in antifungal drug treatments as well.
Method Of Inhibiting Biofilm Formation
US Patent:
2016030, Oct 27, 2016
Filed:
Apr 25, 2016
Appl. No.:
15/137692
Inventors:
- New York NY, US
Edward N. Kennelly - Bronx NY, US
Peter Lipke - Brooklyn NY, US
Edward N. Kennelly - Bronx NY, US
Peter Lipke - Brooklyn NY, US
International Classification:
A01N 35/06
A01N 43/653
A01N 43/653
Abstract:
Xanthochymol and garcinol, isoprenylated benzophenones purified from fruits, showed multiple activities against fungal biofilms. Both compounds effectively prevented emergence of fungal germ tubes and were also cytostatic, with MICs of 1 to 3 ΞM. The compounds therefore inhibited development of hyphae and subsequent biofilm maturation. Xanthochymol treatment of developing and mature biofilms induced cell death. In early biofilm development, killing had the characteristics of apoptosis. These activities resulted in failure of biofilm maturation and hyphal death in mature biofilms. In mature biofilms, xanthochymol and garcinol caused the death of biofilm hyphae, with 50% effective concentrations (ECs) of 30 to 50 μM. Additionally, xanthochymol-mediated killing was complementary with fluconazole against mature biofilms, reducing the fluconazole ECfrom greater than 1,024 μg per ml to 13 μg per ml.
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