Peter T PuglieseBechtelsville, PA

6448251, Sep 10, 2002

Jul 27, 2000

09/627910

Peter T. Pugliese - Reading PA, 19605
Peter M. Pugliese - Reading PA, 19605

A61K 3150

51425212, 514518

A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid moiety, selected from one of the groups consisting of alkanes, alkenes, and alkadienes, each having a hydrocarbon chain of from one to twenty carbon atoms. The resulting HEPES esters are represented by the acetic acid ester as an exemplary alkane, the oleic acid ester as a exemplary alkene, and the linoleic acid ester as an exemplary alkadiene, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties; they occur naturally as glycerides, i. e. , esters of glycerol.

6309656, Oct 30, 2001

Aug 31, 1999

9/386235

Peter T. Pugliese - Reading PA
Steven M. Pugliese - Reading PA

A61K 713
A61K 7075
A61K 31195

424401

A hair and scalp formulation based on a peroxidase enzyme and synergistic yeast extract therefore. It entails a chemically-inert carrier material, a germicidal/preservative agent, and a metal chelating agent. A skin protective formulation based on peroxidase enzyme and yeast extract. It entails a polymer carrier, a fatty acid emollient, a co-emulsifier of an amino acid complex essential to a fatty acid; an emulsifying agent; a skin healing agent, and a germicidal surfactant. An aqueous formulation adapted for topical hair rinsing consisting of a peroxidase enzyme, a yeast extract adapted to enhance the activity of the enzyme and a cationic hair conditioning agent selected from water-soluble thickening resins.

6010685, Jan 4, 2000

Mar 8, 1999

9/264659

John A. Ziemniak - Gwynedd Valley PA
Allen T. Hopper - Somerset NJ
Peter T. Pugliese - Reading PA

Oxis International, Inc. - Portland OR

A61K 742
A61K 700
A61K 3134

424 59

Formulations of racemic or optically active 3,4-dihydroxy-5-aryl-2(5H)-furanoncs are provided for topical administration to the skin for the inhibition and prevention of sunburn cell formation resulting from exposure to ultraviolet radiation and other sources of damage, and for the treatment of skin aging. The compounds may be formulated in combination with a sunscreen, and may be applied before, during, and/or after exposure.