Inventors:
Radha Narayan - Cambridge MA, US
Jeremy S. Disch - Natick MA, US
Robert B. Perni - Marlborough MA, US
Chi B. Vu - Arlington MA, US
Assignee:
Sirtris Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/497
A61K 31/5377
A61K 31/506
A61K 31/47
A61K 31/444
A61K 31/4439
A61K 31/443
A61K 31/4418
C07D 413/14
C07D 491/052
C07D 413/06
C07D 401/12
C07D 215/48
C07D 417/12
C07D 401/06
C07D 405/12
C07D 213/56
A61P 5/50
A61P 3/00
A61P 3/10
A61K 31/4709
US Classification:
51421021, 5142338, 5142352, 5142355, 51425505, 514256, 514275, 514311, 514314, 514332, 514342, 514343, 514336, 514357, 544120, 544127, 544128, 544131, 544328, 544331, 544333, 544405, 546169, 546170, 546262, 5462697, 5462707, 5462764, 5462837, 546337
Abstract:
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.