Randolph Scott Lopez, Age 5916018 Pool Canyon Rd, Austin, TX 78734

2022025, Aug 11, 2022

Jun 1, 2021

17/619506

- Seattle WA, US
Randolph Lopez - Seattle WA, US
Michael Wittekind - Seattle WA, US

C12N 15/10
C12N 1/16
C12N 15/81

Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

2023010, Apr 6, 2023

Aug 31, 2022

17/899860

- Seattle WA, US
Randolph Lopez - Seattle WA, US
Arpita Sen - Seattle WA, US
Ryan Emerson - Seattle WA, US

A-Alpha Bio, Inc. - Seattle WA

C12N 15/10
C12N 1/16
G01N 33/68
C12Q 1/48

Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.

2023000, Jan 5, 2023

Sep 2, 2022

17/901986

- Seattle WA, US
Randolph Lopez - Seattle WA, US
Michael Wittekind - Seattle WA, US

A-Alpha Bio, Inc. - Seattle WA
Olympic Protein Sciences LLC - Seattle WA

G01N 33/68
C12N 15/10
C12N 15/81
C12N 1/16

Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

2018023, Aug 16, 2018

Feb 14, 2017

15/431897

- Redmond WA, US
Karin Strauss - Seattle WA, US
Luis H. Ceze - Seattle WA, US
Lee Organick - Seattle WA, US
Randolph Lopez - Seattle WA, US
Georg Seelig - Seattle WA, US

C12Q 1/68
G06F 19/22

This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.