Renee Cheryl Howell, Age 592323 Lincoln Ave, Sparrows Point, MD 21219
Renee Howell Phones & Addresses
8054 Wallace St, Dundalk, MD 21222 (410) 285-7010 (410) 650-5055
8511 Kavanagh Rd, Dundalk, MD 21222 (410) 388-0263 (410) 388-9117
2300 Vandermast Rd, Essex, MD 21221 (410) 686-1235 (410) 687-0875
Sparrows Point, MD
Columbia, MD
Mentions for Renee Cheryl Howell
Publications & IP owners
Us Patents
Thermal Calibration
US Patent:
2012017, Jul 12, 2012
Filed:
Aug 31, 2011
Appl. No.:
13/223258
Inventors:
Fernando DeCastro - Boyds MD, US
Renee Howell - Rockville MD, US
Sami Kanderian - Germantown MD, US
Johnathan S. Coursey - Germantown MD, US
Kenton C. Hasson - Germantown MD, US
Scott Sundberg - Rockville MD, US
Renee Howell - Rockville MD, US
Sami Kanderian - Germantown MD, US
Johnathan S. Coursey - Germantown MD, US
Kenton C. Hasson - Germantown MD, US
Scott Sundberg - Rockville MD, US
Assignee:
CANON U.S. LIFE SCIENCES, INC. - Rockville MD
International Classification:
G01N 25/04
C09K 3/00
G01K 15/00
C07H 21/04
C09K 3/00
G01K 15/00
C07H 21/04
US Classification:
435 3, 536 231, 2524081, 374 1, 374E15001
Abstract:
The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.
Detection Of Neighboring Variants
US Patent:
2013012, May 16, 2013
Filed:
Nov 16, 2011
Appl. No.:
13/297970
Inventors:
LING XU - ROCKVILLE MD, US
RENEE HOWELL - ROCKVILLE MD, US
RENEE HOWELL - ROCKVILLE MD, US
Assignee:
CANON U.S. LIFE SCIENCES, INC. - ROCKVILLE MD
International Classification:
C12Q 1/68
C12M 1/34
C07H 21/00
C12M 1/34
C07H 21/00
US Classification:
435 611, 435 612, 536 2433, 536 2431, 4352872
Abstract:
The present invention relates to methods, kits, probes, and systems for distinguishing between nucleotide variants that are close in proximity on a gene. The methods, kits, probes, and systems can include the use of a small amplicon assay in combination with two unlabeled probes in a high resolution thermal melting analysis of a biological sample containing a locus of interest in order to discern between disease-causing and benign variants that are close in proximity on a gene within the biological sample. The present invention also relates to method of detecting a disease in a patient based on the patient's genotype by determining whether the patient has a disease-causing variant at a locus of interest. The signature melt curves produced by the unlabeled probe tests can be analyzed using HRMA software to distinguish between disease-causing and benign variants that are close in proximity on a gene within the biological sample.
Methods And Systems For Sequential Determination Of Genetic Mutations And/Or Varients
US Patent:
2012008, Apr 12, 2012
Filed:
Jun 2, 2011
Appl. No.:
13/152260
Inventors:
Jacquline Yancy - Laurel MD, US
Lingxia Jiang - Boyds MD, US
Stephanie Buszczak - Rockville MD, US
Renee Howell - Rockville MD, US
Deborah Boles - Cary NC, US
Lingxia Jiang - Boyds MD, US
Stephanie Buszczak - Rockville MD, US
Renee Howell - Rockville MD, US
Deborah Boles - Cary NC, US
Assignee:
CANON U.S. LIFE SCIENCES, INC. - Rockville MD
International Classification:
C12Q 1/68
US Classification:
435 611
Abstract:
The present invention relates to methods and systems for genome scanning using high resolution melting analysis for identifying mutations and/or variants in genes of interest.
Thermal Calibration
US Patent:
2020026, Aug 20, 2020
Filed:
Mar 16, 2020
Appl. No.:
16/820255
Inventors:
- Melville NY, US
Renee Howell - Rockville MD, US
Sami Kanderian - Germantown MD, US
Johnathan S. Coursey - Germantown MD, US
Kenton C. Hasson - Germantown MD, US
Scott Sundberg - Rockville MD, US
Renee Howell - Rockville MD, US
Sami Kanderian - Germantown MD, US
Johnathan S. Coursey - Germantown MD, US
Kenton C. Hasson - Germantown MD, US
Scott Sundberg - Rockville MD, US
Assignee:
Canon U.S.A., Inc. - Melville NY
International Classification:
G01K 11/06
G01K 15/00
B01L 7/00
B01L 3/00
C12Q 1/6806
G01K 15/00
B01L 7/00
B01L 3/00
C12Q 1/6806
Abstract:
The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.
Detection Of Neighboring Variants
US Patent:
2017000, Jan 12, 2017
Filed:
Sep 19, 2016
Appl. No.:
15/269362
Inventors:
- Rockville MD, US
Renee Howell - Rockville MD, US
Renee Howell - Rockville MD, US
Assignee:
Canon U.S. Life Sciences, Inc. - Rockville MD
International Classification:
C12Q 1/68
Abstract:
The present invention relates to methods, kits, probes, and systems for distinguishing between nucleotide variants that are close in proximity on a gene. The methods, kits, probes, and systems can include the use of a small amplicon assay in combination with two unlabeled probes in a high resolution thermal melting analysis of a biological sample containing a locus of interest in order to discern between disease-causing and benign variants that are close in proximity on a gene within the biological sample. The present invention also relates to method of detecting a disease in a patient based on the patient's genotype by determining whether the patient has a disease-causing variant at a locus of interest. The signature melt curves produced by the unlabeled probe tests can be analyzed using HRMA software to distinguish between disease-causing and benign variants that are close in proximity on a gene within the biological sample.
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