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Richard A Fishel, Age 714400 Elliott Rd, Hilliard, OH 43026

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Known as:
Richard Dr Fishel Richard C Fishel Dick Fishel Rick Fishel Richard L

Richard Fishel Phones & Addresses

4400 Elliott Rd, Hilliard, OH 43026 (614) 850-0077

Durango, CO

575 Sprague Rd, Narberth, PA 19072 (610) 617-4543 (610) 617-4546

Penn Valley, PA

Frederick, MD

Columbus, OH

Shelburne, VT

Amlin, OH

Franklin, OH

Montgomery, PA

575 Sprague Rd, Narberth, PA 19072 (215) 275-0106

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Work

Position: Administrative Support Occupations, Including Clerical Occupations

Education

Degree: Bachelor's degree or higher

Emails

r***[email protected]

Mentions for Richard A Fishel

Richard Fishel resumes & CV records

Resumes

Richard Fishel Photo 35

Richard Fishel

Location:
Columbus, Ohio Area
Industry:
Higher Education
Richard Fishel Photo 36

Richard Fishel

Location:
Columbus, Ohio Area
Industry:
Higher Education

Publications & IP owners

Us Patents

Method For Detection Of Alterations In The Dna Mismatch Repair Pathway

US Patent:
7229755, Jun 12, 2007
Filed:
Nov 1, 1994
Appl. No.:
08/448444
Inventors:
Richard D. Kolodner - Jamaica Plain MA, US
Robert A. G. Reenan - Madison WI, US
Richard Fishel - Penn Valley PA, US
Assignee:
Dana Farber Cancer Institute, Inc. - Boston MA
University of Vermont and State Agricultural College - Burlington VT
International Classification:
C12Q 1/68
A61K 49/00
G01N 33/566
C07K 1/00
C07H 21/04
C12N 15/00
US Classification:
435 6, 424 92, 436501, 530300, 530350, 536 231, 536320, 4353201
Abstract:
We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of unstable repeated DNA sequences. Such a phenotype has a high correlation to disease state in a number of cancers, such as hereditary colon cancers. Accordingly, discovering a defect or alteration in the pathway can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.

Method For Detection Of Alterations In The Dna Mismatch Repair Pathway

US Patent:
7396678, Jul 8, 2008
Filed:
Jun 5, 1995
Appl. No.:
08/465251
Inventors:
Richard D. Kolodner - Jamaica Plain MA, US
Robert A. G. Reenan - Madison WI, US
Richard Fishel - Penn Valley PA, US
Assignee:
Dana-Farber Cancer Institute - Boston MA
University of Vermont and State Agricultural College - Burlington VT
International Classification:
C12P 21/06
C07H 17/00
US Classification:
4353201, 536 231
Abstract:
We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of unstable repeated DNA sequences. Such a phenotype has a high correlation to disease state in a number of cancers, such as hereditary colon cancers. Accordingly, discovering a defect or alteration in the pathway can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer. We have also discovered and sequenced one of the genes in this pathway in a number of mammals, including humans. This gene, referred to herein as MSH2, has many applications. It can be used in assays, to express gene product, for drug screens, and therapeutically. We also disclose herein a method for screening for other genes in this mismatch repair pathway.

Compositions, Kits, And Methods For Effecting Adenine Nucleotide Modulation Of Dna Mismatch Recognition Proteins

US Patent:
2002005, May 16, 2002
Filed:
Aug 22, 2001
Appl. No.:
09/934909
Inventors:
Richard Fishel - Penn Valley PA, US
Scott Gradia - Philadelphia PA, US
Samir Acharya - Philadelphia PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Compositions, and products comprising a MutS homolog which binds to a mismatched region of a duplex DNA molecule in the presence of ADP are provided, as are methods of binding MutS homologs to mismatched DNA in the presence of ADP. The use of MutL homolog derivatives in combination with MutS homologs is also included. Nonhuman mammals which are nullizygous for both Msh2 and p53 are also provided, as are methods of making and using the same.

Methods, Of Identifying Compounds That Modulate A Dna Repair Pathway And/Or Retroviral Infectivity, The Compounds, And Uses Thereof

US Patent:
2005015, Jul 21, 2005
Filed:
Apr 4, 2003
Appl. No.:
10/510363
Inventors:
Richard Fishel - Penn Valley PA, US
Kristine Yoder - Penn Valley PA, US
International Classification:
C12Q001/68
C12N015/867
US Classification:
435006000, 435456000
Abstract:
Retroviruses are RNA viruses that must insert a DNA copy (cDNA) of their genome into the host genome in order to carryout a productive infection. One host cellular pathway that defends against retroviral cDNA integration involves highly conserved proteins of a host DNA repair pathway. These proteins represent novel targets for anti-retroviral drugs. The invention presented herein provides, inter alia, methods of identifying compounds that induce a DNA repair pathway and/or inhibit retroviral cDNA integration into a host genome, compounds thus identified, uses of such compounds, and kits for identifying and testing of the efficacy of compounds in inducing a DNA repair pathway, inhibiting retroviral cDNA integration, and inhibiting retroviral infection.

Method For The Detection Of Microsatellite Instability For Tumor Diagnostics

US Patent:
6150100, Nov 21, 2000
Filed:
Mar 25, 1998
Appl. No.:
9/047347
Inventors:
Josef Ruschoff - Bad Abbach, DE
Wolfgang Dietmaier - Regensburg, DE
Richard Fishel - Penn Valley PA
Assignee:
Roche Diagnostics GmbH - Mannheim
International Classification:
C12Q 168
C12P 1934
C07H 2104
US Classification:
435 6
Abstract:
The invention concerns a method for the determination of the genomic instability at 5 selected microsatellite loci. The analysis of these selected loci is suitable for making prognostic tumour diagnoses, for analysing hereditary tumor predisposition as well as for early tumor detection. This method is of particular importance for the diagnosis of tumors of the gastrointestinal tract such as colorectal tumors.

Compositions, Kits, And Methods For Effecting Adenine Nucleotide Modulation Of Dna Mismatch Recognition Proteins

US Patent:
6333153, Dec 25, 2001
Filed:
Aug 28, 1998
Appl. No.:
9/143571
Inventors:
Richard A. Fishel - Penn Valley PA
Scott Gradia - Philadelphia PA
Samir Acharya - Philadelphia PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C12Q 168
G01N 3353
C12P 1934
C07K 1400
C07H 2104
US Classification:
435 6
Abstract:
Compositions, and products comprising a MutS homolog which binds to a mismatched region of a duplex DNA molecule in the presence of ADP are provided, as are methods of binding MutS homologs to mismatched DNA in the presence of ADP. The use of MutL homolog derivatives in combination with MutS homologs is also included. Nonhuman mammals which are nullizygous for both Msh2 and p53 are also provided, as are methods of making and using the same.

Isbn (Books And Publications)

Bison Hunters Of The Western Prairies: Archaeological Investigations At The Dixon Site (13Wd8), Woodbury County, Iowa

Author:
Richard L. Fishel
ISBN #:
0874141184

Possible Relatives

Cynthia K Fishel  David B Fishel  Daniel S Fishel  Denise E Fishel  Danielle M Fishel  Derek R Fishel  Douglas A Fishel  Richard O Johnson  Richard E Stamps  Richard E Stanbrough 

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