Richard H Moss81 Moss Pt, Gasburg, VA 23857

4322311, Mar 30, 1982

Apr 25, 1980

6/143932

Franklin Lim - Richmond VA
Richard D. Moss - Chester VA

Damon Corporation - Needham Heights MA

B01J 1302

252316

A process for producing microcapsules of controlled porosity containing a chemically active core material. A core material such as a biologically active material and a first monomer in aqueous solution are emulsified in a hydrophobic solvent. A monomer complementary to the first and soluble in the continuous, hydrophobic phase of the emulsion is added to initiate interfacial polymerization about the aqueous droplets. During the course of the reaction, the affinity of the continuous phase for the first monomer is varied by adding a solvent to the continuous phase to vary its polarity. The continuous phase may be relatively nonpolar at the outset and a polar solvent may be added to increase its affinity for the first monomer, or it may be relatively polar at the outset and a nonpolar (or less polar) solvent may be added. This technique allows production of microcapsules having a selected pore size so that, for example, encapsulated material cannot escape, yet lower molecular weight materials can diffuse through the capsule wall.

4324683, Apr 13, 1982

Aug 20, 1975

5/606166

Franklin Lim - Richmond VA
Richard D. Moss - Chester VA

Damon Corporation - Needham Heights MA

B01J 1302
A61K 950

252316

A two step interfacial polymerization process for encapsulating operative chemically active substances in high quality semipermeable membranes. An emulsion is formed wherein the discontinuous phase contains the substance to be encapsulated and a first monomer. When a second monomer is added to the continuous phase, an imperfect membrane forms about the droplets of the discontinuous phase. Removal of the continuous phase, followed by resuspension of the raw microcapsules and addition of a second portion of second monomer, causes further polymerization strengthening the membranes and "patching" macroporous defects in them. The choice of solvents and control of reaction conditions such as pH, maximize the yield of operable labile substance encapsulated. A method of encapsulating a very high concentration of hemoglobin is also disclosed. Adaption of the two step process provides a method for forming and controlling the pore sizes in the membranes of a number of known prior art encapsulation processes.

4255411, Mar 10, 1981

Nov 27, 1978

5/963932

Franklin Lim - Richmond VA
Richard D. Moss - Chester VA

Damon Corporation - Needham Heights MA

A61K 4300
G01N 3348
G01T 100
B01J 1300

424 1

A process for determining an immunogenic substance present in a sample wherein the immunogenic substance in the sample competes with a distinguishable analog of such substance for available binding sites on an antibody which is highly specific for the immunogenic substance in the sample. The antibody is encapsulated in a semi-permeable microcapsule. A specific example of the foregoing procedure is the determination of digoxin present in serum wherein the digoxin in the serum competes with radioiodine labeled digoxin for available binding sites on an antibody which is highly specific for digoxin and has been previously encapsulated in semi-permeable microcapsules. The concentration of digoxin in the sample is determined from a standard curve by relating digoxin concentration inversely to the percent of radioiodine labeled digoxin that is complexed to the antibody.

4389419, Jun 21, 1983

Nov 10, 1980

6/205340

Franklin Lim - Richmond VA
Richard D. Moss - Chester VA

Damon Corporation - Needham Heights MA

A23L 130
B01J 1302

426 72

Disclosed is a process for encapsulating oils and oil-soluble substances in multi-compartmentalized, mechanically stable microcapsules. The process comprises the steps of first forming an emulsion consisting of a continuous phase comprising an aqueous solution of an alkali metal alginate and optionally a water-soluble, alcohol-insoluble filler such as a polysaccharide, and a dispersed phase of an oleophilic substance such as one or more vitamins dissolved in an oil. The emulsion is then formed into droplets which are thereafter immersed in an alcoholic solution of multivalent cations, to produce a shape-retaining alginate matrix filled with precipitated polysaccharide and enclosing plural oil droplets. The vitamins are thereby protected from oxidative degradation and can be handled like conventional crystalline solids.

4911556, Mar 27, 1990

Mar 17, 1989

7/324676

Franklin Lim - Richmond VA
William H. Bingham - Richmond VA
Richard D. Moss - Chester VA

Lim Technology Laboratories, Inc. - Richmond VA

B01F 1308

366279

Efficient mixing is promoted in a turbulent stirring unit by providing an agitator with flexible finger-like appendages and by varying the rate of rotation of a rotating magnetic field such that the fingers execute an undulatory motion, disrupting laminar flow and tending to collapse the liquid vortex. Motor control for controlling the fluctuation of the rotating magnetic field may provided by simple and economical electronic or electromechanical means. The control unit may be separately configured to control a number of other pieces of equipment, either in common or independently. The controller also may be integrated into stirrers, vortexers or shaker tables or externally provided to control existing units.

5120648, Jun 9, 1992

May 26, 1988

7/199229

Franklin Lim - Richmond VA
William H. Bingham - Richmond VA
Richard D. Moss - Chester VA
Lloyd T. Hall - Richmond VA

Lim Technology Laboratories, Inc. - Richmond VA

C12M 140
C12M 134
C12N 1300
G01N 0000

435173

A chemical analyzer in which the measurement of the change in attenuation of RF radiation propagated through a sample is used as the basis for calculating the change in concentration of a given chemical in the sample. Also disclosed are various probe and system designs which facilitate the use of RF attenuation as a basis for measurement of certain chemical characteristics of a sample.

4251387, Feb 17, 1981

Apr 17, 1979

6/030847

Franklin Lim - Richmond VA
Richard D. Moss - Chester VA

Damon Corporation - Needham Heights MA

B01J 1302

252316

Techniques for producing semipermeable microcapsules by interfacial polymerization are disclosed. The material to be encapsulated and a hydrophilic monomer are emulsified within a hydrophobic continuous phase. Polymerization is initiated by dissolving a second monomer in the continuous phase, and occurs only at the interface of the emulsion to result in the formation of macroporous, poorly defined capsule membranes. Next, the affinity of the continuous phase for the hydrophilic monomer is varied by altering the polarity of the continuous phase. This step is accomplished either by isolating and resuspending the raw capsules in a fresh continuous phase of different polar character, or by mixing a second solvent with the continuous phase. By controlling the affinity and the concentration of the second monomer, it is possible to produce microcapsules having uniform capsule membranes and a selected upper limit of permeability.