Robert F Mcquade Deceased321 Harrington Way, Souderton, PA 18964

6498168, Dec 24, 2002

Jul 11, 2001

09/902849

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D40102

514316, 546186, 546187, 546188, 546189

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R , R , R , R , R , R , R , X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

5104814, Apr 14, 1992

Dec 21, 1990

7/631220

Richard Chipkin - West Caldwell NJ
Robert D. McQuade - Scotch Plains NJ

Schering Corporation - Kenilworth NJ

G01N 33567
C07D22316

436504

The invention describes a kit and a method useful for analyzing the plasma concentration of an active neuroleptic drug known to have D-1 receptor antagonist properties utilizing labeled [-]trans 6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo[d]naphtho-[2 ,1-b]-azepine.

5883096, Mar 16, 1999

Feb 16, 1996

8/602403

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W. Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D29508
C07D30781
C07D33358
A61K 31495

514252

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl; X is --O--, --SO. sub. 0-2 --, amino, substituted amino, --CO--, --CH. sub. 2 --, mono or di-substituted methylene, --CS--, --CONR. sup. 20 --, --NR. sup. 20 --SO. sub. 2 --, --NR. sup. 20 CO--, --SO. sub. 2 NR. sup. 20 --, --CH. dbd. CH--, --C. tbd. C-- or --NHC(O)NH--; R is optionally substituted phenyl, aryl or cycloalkyl, or other substituents as defined in the specification; R. sup. 1 and R. sup. 21 are H, CN or optionally substituted alkyl, or other substituents as defined in the specification; R. sup. 2 is optionally substituted cycloalkyl or piperidyl, or other substituents as defined in the specification; and R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 20, R. sup. 27 and R. sup. 28 are as defined in the specification; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease; pharmaceutical compositions and methods of preparation are also disclosed, as well as synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

6037352, Mar 14, 2000

Nov 19, 1998

9/195742

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

A61K 31445
C07D21100
C07D21108

514316

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 21, R. sup. 27, R. sup. 28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

6043255, Mar 28, 2000

Mar 10, 1999

9/266079

Derek B. Lowe - Scotch Plains NJ
Wei K. Chang - Livingston NJ
Joseph A. Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Yuguang Wang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Encinitas CA
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ
Craig D. Boyle - Bridgewater NJ

Schering Corporation - Kenilworth NJ

A61K 31445
C07D40102

514316

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 21, R. sup. 27, R. sup. 28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.

6288068, Sep 11, 2001

Jan 12, 2000

9/482168

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Javaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D 31495
A61K24136

514256

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 21, R. sup. 27, R. sup. 28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

5889006, Mar 30, 1999

Aug 8, 1996

8/700628

Derek B. Lowe - Scotch Plains NJ
Wei K. Chang - Livingston NJ
Joseph A. Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W. Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Yuguang Wang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Encinitas CA
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ
Craig D. Boyle - Bridgewater NJ

Schering Corporation - Kenilworth NJ

C07D40102
C07D40302
C07D40314
C07D40114

519252

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 21, R. sup. 27, R. sup. 28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.