Inventors:
Michael P. Fleming - Longmont CO, US
Yeun-Kwei Han - Louisville CO, US
Lewis M. Hodges - Longmont CO, US
David A. Johnston - Louisville CO, US
Roger P. Micheli - Louisville CO, US
Kurt Puentener - Basel, CH
Chris R. Roberts - Berthoud CO, US
Michelangelo Scalone - Birsfelden, CH
Mark A. Schwindt - Boulder CO, US
Robert J. Topping - Longmont CO, US
Assignee:
Roche Colorado Corporation - Boulder CO
International Classification:
C07C069/66
Abstract:
The present invention relates to a novel process for producing a δ-lactone of the formula: using an acyl halide of the formula: wherein R, RRand X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-δ-lactone.