Roy D Archibald, Age 86Happy Valley, OR

D603525, Nov 3, 2009

Oct 10, 2008

29/326079

James Foreman - Crystal Lake IL, US
David Mufson - San Francisco CA, US
Roy Duane Archibald - Sonora CA, US
Randal R. Schettl - Crystal Lake IL, US

Insite Vision Incorporated - Alameda CA
Catalent Pharma Solutions - Somerset NJ

2401

D24232

7795231, Sep 14, 2010

Oct 4, 2007

11/905854

Lyle Bowman - Pleasanton CA, US
S. Kumar Chandrasekaran - Moraga CA, US
Roy Duane Archibald - Sonora CA, US
Stephen Pham - Sacramento CA, US
David Mufson - San Francisco CA, US

Insite Vision Incorporated - Alameda CA

A61K 31/00

514 28

The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.

2010030, Dec 2, 2010

Aug 12, 2010

12/855096

Lyle Bowman - Pleasanton CA, US
S. Kumar Chandrasekaran - Moraga CA, US
Roy Duane Archibald - Sonora CA, US
Stephen Pham - Sacramento CA, US
David Mufson - San Francisco CA, US

INSITE VISION INCORPORATED - Alameda CA

A61K 31/7052
A61P 33/02
A61P 31/04
A61P 29/00

514 29

The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.

5040706, Aug 20, 1991

Mar 17, 1989

7/324793

Jeffrey P. Davis - Madison WI
Roy D. Archibald - Fremont CA
Christa D. Nicholas - Alameda CA
Santosh K. Chandrasekaran - Moraga CA

InSite Vision, Inc. - Alameda CA

B65D 1724
B65D 4710
A61M 100

222541

A disposable unit- or multi-dose liquid dispensing container device, particularly adapted for delivery of ophthalmic liquid medicament in the form of discrete droplets to the eye. The structural configuration of the device including an angularly offset leading end permits the user to employ a free hand for manipulation of the eyelid to enhance reception of the discharge opening of the dispenser into the conjunctival cul-de-sac while at the same time, enabling the user to look directly into a wall-mounted mirror for accurate placement of the medicament. A small capacity reservoir and ease of control of accurate orifice size enables the application of uniform liquid-ejection pressure by the user to deliver droplets of reproducible dosage size with the multi-dose embodiment.

4267167, May 12, 1981

May 27, 1980

6/153089

Stewart Weitzman - Portland OR
Roy D. Archibald - Gresham OR

Cooper Care, Inc. - Palo Alto CA

A61K 718
A61K 3316
A61K 3342

424 52

A thixotropic acidulated phosphate fluoride composition for the control and prevention of dental caries is disclosed.

5188826, Feb 23, 1993

Jul 6, 1990

7/549093

Santosh K. Chandrasekaran - Moraga CA
Margaret J. Reents - Alameda CA
John C. Babcock - Olga WA
Lyle M. Bowman - Pleasanton CA
Roy D. Archibald - Fremont CA
Joseph R. Robinson - Madison WI

InSite Vision Incorporated - Alameda CA

A61K 908
A01N 2502

424 7804

A topical, aqueous ophthalmic gel suspension for dry eye is administrable to the eye in drop form, remains as a gel in the eye for a prolonged time, and releases water and one or more ophthalmic demulcents or vasoconstrictors. It comprises water and from 0. 1% to 6. 5% by weight of lightly cross-linked carboxyl-containing polymer having a particle size of not more than about 50. mu. m in equivalent spherical diameter. The suspension is at a pH of from 6. 6 to 8. 0, has an osmolality of from 50 to 400 mOsM, and a viscosity of from about 500 to about 4,000 centipoise (0. 5 to 4 Pa. s).

5192535, Mar 9, 1993

Jun 27, 1990

7/544518

Jeffrey P. Davis - Madison WI
Santosh K. Chandrasekaran - Moraga CA
Yansheng Su - Shandong, CN
Roy D. Archibald - Fremont CA
Joseph R. Robinson - Madison WI

InSite Vision Incorporated - Alameda CA

A61F 214
A61K 964
A61K 970
A61K 31765

424 7804

Lightly crosslinked polymers, preferably ones prepared by suspension or emulsion polymerizing at least about 90% by weight of a carboxyl-containing monoethylenically unsaturated monomer such as acrylic acid with from about 0. 1% to about 5% by weight of a polyfunctional, and preferably difunctional, crosslinking agent such as divinyl glycol (3,4-dihydroxy-1,5-hexadiene), having a particle size of not more than about 50. mu. m in equivalent spherical diameter, when formulated with an ophthalmic medicament, e. g. , fluorometholone, into suspensions in aqueous medium in which the amount of polymer ranges from about 0. 1% to about 6. 5% by weight, based on the total weight of the aqueous suspension, the pH is from about 3. 0 to about 6. 5, and the osmotic pressure (osmolality or tonicity) is from about 10 mOsM to about 400 mOsM, provide new topical ophthalmic medicament delivery systems having suitably low viscosities which permit them to be easily administered to the eye in drop form, and hence be comfortably administrable in consistent, accurate dosages.