Inventors:
Sidney Hecht - Phoenix AZ, US
Ryan Schmaltz - La Jolla CA, US
Krystal Tsosie - Phoenix AZ, US
Assignee:
Arizona Board of Regents, a body corporate of the State of Ariz. acting for and on behalf of Ariz. - Scottdale AZ
International Classification:
A61K 49/22
A61K 38/14
A61P 35/00
C07H 15/26
A61K 31/7056
C07K 9/00
A61K 49/00
US Classification:
424 952, 530322, 514 209, 424 96, 514 193, 424 941, 536 179, 536 174, 514 25
Abstract:
Tumors can be selectively targeted via compounds provided herein according to the formula, or a pharmaceutically acceptable salt thereof, wherein Rand Rare as defined herein. Tumors can be imaged or targeted for therapeutic treatment using compounds described herein where at least one Ror at least one Rgroup comprises a imaging agent, a therapeutic agent, or a member of a specific binding pair which can be associated with a secondary imaging agent, such as a microbubble for ultrasonic imaging.