Ryan G Toomey, Age 5117811 Arbor Creek Dr, Tampa, FL 33647

8163418, Apr 24, 2012

Nov 11, 2008

12/268772

Norma A. Alcantar - Tampa FL, US
Xiaoling Ding - Xiaoling FL, US
Ryan G. Toomey - Tampa FL, US
Lawrence C. Langebrake - Seminole FL, US

University of South Florida - Tampa FL

H01M 6/30
H01M 4/36

429110, 429118, 429122, 429206, 429219

A system and method for improving electrochemical power sources through the dispensing, encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.

8501338, Aug 6, 2013

Apr 20, 2011

13/090801

Norma A. Alcantar - Tampa FL, US
Xiaoling Ding - St. Petersburg FL, US
Ryan G. Toomey - Tampa FL, US
Lawrence C. Langebrake - Seminole FL, US

University of South Florida - Tampa FL

H01M 6/30
H01M 4/36

429118, 429 52, 429110, 429219, 4292318

A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.

2008000, Jan 3, 2008

Apr 16, 2007

11/735743

Ryan Toomey - Tampa FL, US
Peter Stroot - Lutz FL, US

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

C12N 13/00
B01D 57/02

435173900, 204547000

The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate cell movement as dictated by the intrinsic dielectric constant of the cell without modification. DEP therefore provides a mechanism by which to force targets in a flow channel to a reversible binding surface. By building selectivity into the binding surface, the capacity to choose which targets can be held after the dielectric field is turned off, providing a separation strategy that does not suffer from fouling issues, as large foulants can freely pass over the surface through the flow channel.

2008005, Feb 28, 2008

Apr 19, 2007

11/737271

Norma Alcantar - Tampa FL, US
Kristina Dearborn - Tampa FL, US
Michael VanAuker - Wesley Chapel FL, US
Ryan Toomey - Tampa FL, US
Elizabeth Hood - Tampa FL, US

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

A61K 9/50

424490

Taught herein is a drug-delivery system that includes encapsulating a therapeutic drug in a nanoparticle vesicle that is then embedded into a hydrogel network. The system allows for enhanced, two-fold control over the release rate of the drug. This technology will be particularly advantageous in treating malignant cancer cells such as those found in the brain. The invention will allow for decreased side effects and increased survival time in patients. This invention opens the door to other technological applications that require controlled release of chemical substances.

2010006, Mar 18, 2010

Nov 20, 2009

12/622693

Norma Alcantar - Tampa FL, US
Eva C. Williams - Tampa FL, US
Ryan Toomey - Tampa FL, US

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

A61K 9/127

424450

Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) packaged within a biodegradable, temperature and pH sensitive hydrogel network was developed. Drug behaviors were modeled using a fluorescent dye with similar physical properties as therapeutic drugs for cancer. The niosomes were embedded into a biodegradable hydrogel providing a stable niosome environment. A cross linked chitosan was used as the hydrogel, which is a liquid at room temperature, and gels inside the body. Depending on the conditions to which individual niosomes are exposed, the release rate can be controlled to last from 24 hours to more than 3 months.

7943259, May 17, 2011

Dec 18, 2007

11/958841

Norma Alcantar - Tampa FL, US
Xiaoling Ding - St. Petersburg FL, US
Ryan G. Toomey - Tampa FL, US
Larry Langebrake - Seminole FL, US

University of South Florida - Tampa FL

H01M 8/16

429401, 429523

A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.

2020035, Nov 12, 2020

Oct 6, 2016

15/766627

MICHAEL C. CROSS - Tampa FL, US
OLUKEMI O. AKINTEWE - Quincy MA, US
SAMUEL JAMES DUPONT - Tampa FL, US
KRANTHI KUMAR ELINENI - Hillsboro OR, US
RYAN G. TOOMEY - Tampa FL, US
NATHAN D. GALLANT - Tampa FL, US

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

C12N 5/00
C12M 3/00
B33Y 10/00
B33Y 80/00

The invention pertains to methods and apparatuses for rapid production of organized tissue precursors with different sizes and geometry. An embodiment of the invention provides a method of producing 3D tissue structures, the method comprising: producing a plurality of patterned monolayers of cells and sequentially overlaying the plurality of patterned monolayers of cells to produce a stack of monolayers of cells. The patterns of cells in the plurality of monolayers can be designed in a manner which produces a tissue or a portion of a tissue when the plurality of monolayers is overlaid in to a stack. The invention also pertains to an apparatus for producing a 3D tissue module. The apparatus comprises: a three-dimensional positioning system, a contact stamp, a contact stamp storage container, a contact stamp holder, a contact stamp exchange unit, and a contact stamp actuator.

2019032, Oct 31, 2019

Jul 3, 2019

16/502850

Norma A. Alcantar - Tampa FL, US
David Morgan - Clearwater FL, US
Zeinab Veisi - Tampa FL, US
Leonid Breydo - Tampa FL, US
Vladimir N. Uversky - Tampa FL, US
Ryan G. Toomey - Tampa FL, US
Tunan Peng - Odessa FL, US
Eva Stephanie Lobbens - Farum, DK

University of South Florida - Tampa FL

A61K 36/33
A61M 5/142
A61P 25/28

A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from -indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.