Inventors:
- Los Gatos CA, US
Geoff McKinley - Los Gatos CA, US
Scott Borland - Los Gatos CA, US
Miguel Guzman - Los Gatos CA, US
Armin Szabolcs - Szombathely, HU
Janos Gerencser - Budapest, HU
International Classification:
C07D 471/06
C07D 495/06
Abstract:
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT, 5-HTand 5-HTreceptors without agonizing the 5-HTreceptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HTadrenergic alphaand/or the alphareceptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.