Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Westlake Village CA, US
Brian K. Albrecht - Cambridge MA, US
Michael D. Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Watertown MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Dean Hickman - Moorpark CA, US
Dan Horne - Thousand Oaks CA, US
Randall Hungate - San Francisco CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Ventura CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/352
C07D 311/96
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.