Shashi P Desai, Age 494545 Cimarron River Ct, San Jose, CA 95136

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4545 Cimarron River Ct, San Jose, CA 95136 (408) 559-6895

1281 Karie Ann Way, San Jose, CA 95118 (408) 448-1765

Campbell, CA

Santa Clara, CA

Union City, CA

Canoga Park, CA

Chesterfield, MO

Chatsworth, CA

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Us Patents

Methods For Estimating Analyte-Related Signals, Microprocessors Comprising Programming To Control Performance Of The Methods, And Analyte Monitoring Devices Employing The Methods

US Patent:
7699775, Apr 20, 2010
Filed:
Oct 13, 2004
Appl. No.:
10/963853
Inventors:
Shashi P. Desai - San Jose CA, US
Timothy C. Dunn - San Francisco CA, US
Matthew J. Lesho - San Carlos CA, US
Russell O. Potts - San Francisco CA, US
Janet A. Tamada - Stanford CA, US
Charles W. Wei - Fremont CA, US
Assignee:
Animas Technologies, LLC - West Chester PA
International Classification:
A61B 5/00
US Classification:
600365, 600309, 600345, 600347
Abstract:
The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e. g. , when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.

Methods For Improving The Performance Of An Analyte Monitoring System

US Patent:
2003005, Mar 13, 2003
Filed:
Jun 21, 2002
Appl. No.:
10/176965
Inventors:
Shashi Desai - San Jose CA, US
Timothy Dunn - San Francisco CA, US
Matthew Lesho - San Carlos CA, US
Russell Potts - San Francisco CA, US
Janet Tamada - Stanford CA, US
Charles Wei - Fremont CA, US
International Classification:
A61B005/05
US Classification:
600/347000
Abstract:
The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.

On-Demand Analyte Monitor And Method Of Use

US Patent:
2008031, Dec 18, 2008
Filed:
Jun 14, 2007
Appl. No.:
11/763414
Inventors:
Arvind N. Jina - San Jose CA, US
Beelee Chua - Davis CA, US
Shashi P. Desai - San Jose CA, US
Abdel-Nasser Kawde - Fremont CA, US
Assignee:
ArKal Medical, Inc - Fremont CA
International Classification:
A61B 5/00
US Classification:
600345
Abstract:
An analyte monitor is provided with a sensor unit body configured for mounting on tissue, a sensor configured to detect an analyte in a fluid in the sensing area, an output device configured to communicate a result from the sensor to a user; and a user input device coupled with the sensor and the output device, wherein the monitor is configured to communicate a result to the user through the output device only after the user input device is activated. Systems, sensors and methods associated with the monitor are also disclosed.

Microneedle Array With Diverse Needle Configurations

US Patent:
2009009, Apr 16, 2009
Filed:
Oct 12, 2007
Appl. No.:
11/871806
Inventors:
Arvind N. Jina - San Jose CA, US
Shashi P. Desai - San Jose CA, US
Beelee Chua - Davis CA, US
Ashok Parmar - Fremont CA, US
Assignee:
ArKal Medical, Inc. - Fremont CA
International Classification:
A61B 5/00
US Classification:
600309
Abstract:
The invention relates to a surface penetration device, a method to use the device, and an analyte monitor. Embodiments of the surface penetration device include a substrate with first and second surfaces, and first and second tissue piercing elements, the elements differing in configuration, but each associated with the first surface of the substrate. At least some of the tissue piercing elements have a distal and a proximal opening and a lumen extending between the openings. The proximal openings are in fluid communication with an opening in the second surface of the substrate. Embodiments of the analyte monitor include the features of the penetration device plus an analyte sensor that detects an analyte in a fluid. Embodiments of the method of penetrating tissue include providing a surface penetration device and urging the surface penetration device against a tissue surface until some of the first and second tissue piercing elements penetrate the tissue surface.

Devices, Systems, Methods And Tools For Continuous Glucose Monitoring

US Patent:
2009013, May 21, 2009
Filed:
Nov 20, 2008
Appl. No.:
12/275145
Inventors:
Arvind N. Jina - San Jose CA, US
Beelee Chua - Fremont CA, US
Janet Tamada - Stanford CA, US
Michael J. Tierney - San Jose CA, US
Shashi P. Desai - San Jose CA, US
International Classification:
A61B 5/145
US Classification:
600365
Abstract:
One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing volume in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending into the sensing volume; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing volume. Another aspect of the invention provides A method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each comprising a distal opening, a proximal opening, and an interior space extending between the distal and proximal opening; allowing interstitial fluid to flow into the interior space of the tissue piercing elements to substantially fill the interior space; filling substantially the entire interior space of the sensing area; and sensing a glucose concentration of the sensing fluid.

Devices, Systems, Methods And Tools For Continuous Analyte Monitoring

US Patent:
2010004, Feb 25, 2010
Filed:
Aug 20, 2009
Appl. No.:
12/545008
Inventors:
Arvind N. Jina - San Jose CA, US
Ashok Parmar - Fremont CA, US
Beelee Chua - Fremont CA, US
Janet Tamada - Stanford CA, US
Jonathan Lee - Sunnyvale CA, US
Michael J. Tierney - San Jose CA, US
Navneet Kaur - Fremont CA, US
Paul Magginetti - San Carlos CA, US
Shashi P. Desai - San Jose CA, US
International Classification:
A61B 5/1468
US Classification:
600345
Abstract:
One aspect of the invention provides an analyte monitor including a sensing volume, an analyte extraction area in contact with the sensing volume adapted to extract an analyte into the sensing volume, and an analyte sensor adapted to detect a concentration of analyte in the sensing volume. The sensing volume is defined by a first face, a second face opposite to the first face, and a thickness equal to the distance between the two faces. The surface area of the first face is about equal to the surface area of the second face and the extraction area is about equal to the surface area of the first and second face of the sensing volume. The analyte sensor includes a working electrode in contact with the sensing volume, the working electrode having a surface area at least as large as the analyte extraction area, and a second electrode in fluid communication with the sensing volume.

Pump Arrangement In Continuous Analyte Monitoring

US Patent:
2012017, Jul 5, 2012
Filed:
Jan 5, 2011
Appl. No.:
12/985234
Inventors:
Varun Boriah - Union City CA, US
Janet Tamada - Stanford CA, US
Arvind N. Jina - San Jose CA, US
Michael J. Tierney - San Jose CA, US
Shashi P. Desai - San Jose CA, US
International Classification:
A61B 5/145
US Classification:
600365
Abstract:
A method of monitoring an analyte (such as, e.g., glucose) including the following steps: diffusing the analyte from a sampling location into a sensing fluid within a sensing chamber; detecting a concentration of the analyte in the sensing fluid; moving flushing fluid into the sensing chamber and simultaneously removing sensing fluid from the sensing chamber; permitting the flushing fluid to remain in the sensing chamber without flowing for a dwell time; removing the flushing fluid from the sensing chamber after the dwell time expires; and, after removing the flushing fluid from the sensing chamber, moving sensing fluid into the sensing chamber. The invention also includes an analyte monitoring device performing this method.

Devices And Methods For Enhanced Skin Perforation For Continuous Glucose Monitoring

US Patent:
2017018, Jul 6, 2017
Filed:
Dec 9, 2016
Appl. No.:
15/374677
Inventors:
- San Jose CA, US
Janet TAMADA - Stanford CA, US
Shashi DESAI - San Jose CA, US
Jonathan LEE - San Carlos CA, US
Assignee:
Arkal, Inc. - San Jose CA
International Classification:
A61B 5/145
A61B 5/00
Abstract:
The efficacy of tissue piercing elements in the area of transdermal drug delivery is well-documented. Multiple studies have shown that enhancement of skin permeation via creation of microscopic pores in the stratum corneum can greatly improve the delivery rates of drugs. However, skin perforation with tissue piercing elements is not the only factor affecting the rate of drug transport. Other factors including such as the formulation of the drug and rate of closure of the micropores closure also need to be considered. Similarly micro tissue piercing elements have been used with less success by several workers for continuous glucose monitoring.

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