Shashidhar U Rao, Age 80301 Wingate Dr, Schaumburg, IL 60193

6525059, Feb 25, 2003

Feb 24, 2000

09/513351

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Paul W. Collins - Deerfield IL
Joyce Zuowu Crich - Glenview IL
Rajesh Devraj - Chesterfield MO
Daniel L. Flynn - Clarkson Valley MO
Lifeng Geng - Skokie IL
Matthew J. Graneto - Chesterfield MO
Cathleen E. Hanau - Chesterfield MO
Gunnar J. Hanson - Skokie IL
Susan J. Hartmann - Kirkwood MO
Michael Hepperle - St. Charles MO
He Huang - Chicago IL
Francis J. Koszyk - Prospect Heights IL
Shuyuan Liao - Northbrook IL
Suzanne Metz - Chesterfield MO
Richard A. Partis - Evanston IL
Thao D. Perry - Chesterfield MO
Shashidhar N. Rao - Mundelein IL
Shaun Raj Selness - St. Louis MO
Michael S. South - St. Louis MO
Michael A. Stealey - Libertyville IL
John Jeffrey Talley - St. Louis MO
Michael L. Vazquez - Ballwin MO
Richard M. Weier - Lake Bluff IL
Xiangdong Xu - Gurnee IL
Ish K. Khanna - Libertyville IL
Yi Yu - Skokie IL

G. D. Searle Company - Skokie IL

A61K 31506

514256, 544333, 544335

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R , R , R and R are as described in the specification.

6689754, Feb 10, 2004

Apr 8, 1999

09/289140

Nizal Samuel Chandrakumar - Vernon Hills IL
Bipinchandra Nanubhai Desai - Vernon Hills IL
Balekudru Devadas - Chesterfield MO
Alan Frank Gasiecki - Vernon Hills IL
Renee Huff - Park Ridge IL
Ish K. Khanna - Vernon Hills IL
James W. Malecha - Libertyville IL
Julie M. Miyashiro - Skokie IL
Shashidhar N. Rao - Mundelein IL
Joseph Gerace Rico - Ballwin MO
Thomas Edward Rogers - Ballwin MO
Peter Gerrard Ruminski - Dardenne Prairie MO
Mark Andrew Russell - Gurnee IL
Yi Yu - Skokie IL

G. D. Searle Co. - Chicago IL

C07K 506

514 20, 514 19, 546304

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the integrin.

6696449, Feb 24, 2004

Jul 19, 2001

09/909227

Thomas E. Barta - Evanston IL
Daniel P. Becker - Glenview IL
Louis J. Bedell - Prospect Heights IL
Gary A. DeCrescenzo - St. Charles MO
John N Freskos - Clayton MO
Daniel P. Getman - Chesterfield MO
Joseph J. McDonald - Wildwood MO
Brent V. Mischke - Defiance MO
Shashidhar N. Rao - Saint Louis MO
Clara I. Villamil - Glenview IL

Pharmacia Corporation - St. Louis MO

A61K 31496

51425503, 51425212, 51425218, 514309, 514312, 514331, 514469, 514575, 544360, 544383, 546141, 546153, 546233, 546234, 546331

This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: wherein W , the R groups, and âAâRâEâY are described in more detail in Applicants specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.

2004012, Jul 1, 2004

Nov 20, 2003

10/718328

Nizal Chandrakumar - Vernon Hills IL, US
Bipinchandra Desai - Vernon Hills IL, US
Balekudru Devadas - Chesterfield MO, US
Alan Gasiecki - Vernon Hills IL, US
Renee Huff - Park Ridge IL, US
Ish Khanna - Vernon Hills IL, US
James Malecha - Libertyville IL, US
Julie Miyashiro - Skokie IL, US
Shashidhar Rao - Mundelein IL, US
Joseph Rico - Ballwin MO, US
Thomas Rogers - Ballwin MO, US
Peter Ruminski - Dardenne Prairie MO, US
Mark Russell - Gurnee IL, US
Yi Yu - Skokie IL, US

G. D. Searle & Co. - Chicago IL

A61K031/54
A61K031/537
A61K031/495
A61K031/44
A61K031/426
A61K031/421
A61K031/401

514/183000, 514/217110, 514/227500, 514/237500, 514/255010, 514/317000, 514/370000, 514/374000, 514/377000, 514/398000, 514/423000, 544/059000, 544/162000, 544/382000, 546/306000, 548/190000, 548/230000, 548/531000

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the integrin.

2005007, Apr 7, 2005

Jun 14, 2004

10/867391

Louis Bedell - Prospect Heights IL, US
Joseph McDonald - Wildwood MO, US
Thomas Barta - Chapel Hill NC, US
Daniel Becker - Glenview IL, US
Shashidhar Rao - Plainsboro NJ, US
John Freskos - Clayton MO, US
Brent Mischke - Defiance MO, US
Daniel Getman - Chesterfield MO, US
Gary DeCrescenzo - St. Charles MO, US
Clara Villamil - Glenview IL, US

C07D211/84
A61K031/44
A61K031/4015

514345000, 514424000, 546294000, 548530000

A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

5773644, Jun 30, 1998

Mar 27, 1997

8/825040

Barbara B. Chen - Glenview IL
Helen Y. Chen - Livingston NJ
Michael Clare - Skokie IL
Shashidhar N. Rao - Mundelein IL
Mark A. Russell - Gurnee IL

G. D. Searle & Co. - Chicago IL

C07C24100
C07C22900
C07D23900

562439

The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the. alpha. sub. v. beta. sub. 3 integrin.

5449674, Sep 12, 1995

Mar 3, 1994

8/204175

Timothy J. Hagen - Gurnee IL
Nizal S. Chandrakumar - Vernon Hills IL
E. Ann Hallinan - Evanston IL
Shashidhar N. Rao - Mundelein IL
Barnett S. Pitzele - Skokie IL

G. D. Searle & Co. - Chicago IL

A61K 3155
C07D26720
C07D28116

514211

The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.