Shiping Te Chen, Age 6224310 Pine Canyon Fls, Tomball, TX 77375

6644111, Nov 11, 2003

Feb 6, 2003

10/248666

Sheldon J. Cytron - Mountain Lakes NJ
Christopher J. LaVigna - Olney MD
Harry G. Kwatny - Elkins Park MD
Justin M. Bowlus - Hyattsville MD
Shiping Chen - Fremont CA

The United States of America as represented by the Secretary of the Army - Washington DC

G01L 514

73167, 73 3515, 7351426, 356 28

An apparatus for measuring exit velocity of a round from a muzzle of a gun barrel includes a first optical fiber having a first fiber optic Bragg grating (FBG) circumferentially attached to the gun barrel at the muzzle and a second FBG circumferentially attached to the gun barrel further from the muzzle than the first FBG; a coupler that receives one end of the first optical fiber; a light source connected by a second optical fiber to the coupler for supplying light to the first optical fiber; a third optical fiber comprising an FBG notch filter, the third optical fiber being connected to the coupler to receive light reflected from the first optical fiber; a notch filter mount attached to the gun barrel, the FBG notch filter being disposed in the notch filter mount; a photodetector connected to an end of the third optical fiber; and data processing electronics electrically connected to the photodetector.

7797342, Sep 14, 2010

Aug 17, 2007

11/840306

Barbara J. Banks - Berkeley CA, US
Rajnish Kumar Chitkara - Fremont CA, US
Shiping Chen - Pleasanton CA, US

Sybase, Inc. - Dublin CA

G06F 17/30

707783, 707999002, 707999009, 707999107, 713166, 713190

A database system providing encrypted column data support with decrypt default functionality. In a database system, a method providing automated encryption support for column data comprises steps of: defining Structured Query Language (SQL) extensions for creating and managing column encryption keys and database tables with encrypted column data; receiving an SQL statement specifying creation of a column encryption key; receiving an SQL statement specifying creation of a database table having particular column data encrypted with the column encryption key; receiving an SQL statement specifying a default value to be provided in response to requests for the column data without decrypt permission; in response to a subsequent database operation requesting encrypted column data from a user with decrypt permission, automatically decrypting the column data; and in response to a subsequent database operation requesting the encrypted column data from a user without decrypt permission, returning the default value.

2002002, Mar 7, 2002

Feb 22, 2001

09/791410

Jianming Xiao - Fremont CA, US
Shiping Chen - Rockville MD, US
Yuling Luo - Castro Valley CA, US
Anthony Chen - Sunnyvale CA, US

B01J019/00

422/100000, 422/099000, 422/102000, 422/130000, 422/131000

Disclosed are systems and methods involved in ultra high throughput screening of chemical compounds which have an affinity for or interact with a biological target. The invention utilizes an apparatus for ultra high throughput screening of chemical compounds for a biological target. The system is based on a capillary bundle that has two distinguishable ends. Capillaries on one end are connected to chemical compounds stored in discrete reservoirs such as micro titer plate wells; capillaries on the other end are tightly bound and then processed to form a two dimensional array that enable the parallel reactions of a target and many different compounds.

2002016, Nov 7, 2002

Feb 19, 2002

10/080274

Jianming Xiao - Fremont CA, US
Shiping Chen - Fremont CA, US
Yuling Luo - Castro Valley CA, US
John Butler - San Jose CA, US
Masoud Qazan - Castro Valley CA, US
Jochen Thiele - Mountain View CA, US
Anthony Chen - Sunnyvale CA, US

G01N033/545
C12M003/00

436/524000, 422/102000, 422/100000, 436/531000, 435/287200, 435/288400, 216/002000

Disclosed are systems and methods involved in extreme high throughput screening of compounds which have an affinity for a biological target. The system is based on a capillary bundle with two distinguishable ends wherein capillaries on one end are connected to compounds stored in discrete reservoirs and capillaries on the other end are bound and processed to form a two dimensional microarray. A capillary bundle having reaction wells for hybridization and compound reaction in one end of the capillaries is disclosed. The capillaries may be light-conducting. Also disclosed are various methods of identifying a target compound in a liquid using this capillary bundle as well as methods of fabricating the bundle. A novel surface tension guided reaction chamber is also provided. Methods and chemistry for fabrication and use of a surface tension guided reaction chamber in binding and hybridization assays are also disclosed. Methods and systems for precise metering of fluids within the capillaries and at the reaction chambers, including the surface tension guided “virtual” reaction well is provided. Methods for performing high throughput screens using optical fiber lined capillaries of the invention are also provided. The capillary arrays are used with both liquid probes as well as probes immobilized on the walls of the capillary.

2003008, May 8, 2003

Oct 4, 2002

10/264892

Shiping Chen - Fremont CA, US
Jianming Xiao - Fremont CA, US
Kaijun Li - San Jose CA, US
Hoang Nguyen - San Jose CA, US

C12Q001/68
C12M001/34

435/006000, 435/287200, 435/286500

Methods and apparatus for promoting interactions between an array of probes deposited on a microarray substrate and target molecules in a target liquid are provided. A microarray apparatus can include a substrate having an array of probes deposited on a surface of the substrate for interaction with a target molecule in a target liquid. The apparatus also includes a cover coupled to the substrate to form a reaction chamber therebetween, wherein the array of probes is contained within the reaction chamber and the substrate and the cover are movable relative to each other.

2003008, May 8, 2003

Aug 27, 2002

10/229571

Shiping Chen - Fremont CA, US

B01J019/00
G01N033/48

435/007100, 422/068100, 436/518000

Systems and methods involved in extreme high throughput screening of compounds which have an affinity for a biological target are disclosed. The system is based on a capillary bundle with two distinguishable ends wherein capillaries on one end are connected to compounds stored in discrete reservoirs and capillaries on the other end are bound and processed to form a two dimensional microarray. A capillary bundle having reaction wells for hybridization and compound reaction in one end of the capillaries is disclosed. Also disclosed are various methods of identifying a target compound in a liquid using this capillary bundle as well as methods of fabricating the bundle. A novel surface tension guided reaction chamber is also provided. Methods and chemistry for fabrication and use of a surface tension guided reaction chamber in binding and hybridization assays are also disclosed. Methods and systems for precise metering of fluids within the capillaries and at the reaction chambers, including the surface tension guided “virtual” reaction well are provided.

2003012, Jul 3, 2003

Nov 14, 2002

10/295230

Shiping Chen - Fremont CA, US
Yuling Luo - Castro Valley CA, US
Anthony Chen - Sunnyvale CA, US
Theo Nikiforov - San Jose CA, US
Jianming Xiao - Fremont CA, US
Quan Nguyen - Pleasant Hills CA, US

C12Q001/68
G01N033/53
C12M001/34

435/006000, 435/007100, 435/287200

Systems and methods of biochemical analysis are provided. A method of performing biochemical assays includes loading a first plurality of reservoirs on a first liquid carrier with a first plurality of compounds, coupling a second carrier with the first carrier, the second carrier having a second plurality of reservoirs configured to couple with the first plurality of reservoirs and containing a second plurality of compounds, transferring at least a portion of the first plurality of compounds to the second plurality of reservoirs, and separating at least one component from the second plurality of reservoirs. A system for biochemical analysis includes a first carrier and a second carrier. The first carrier includes a first substrate and a plurality of reservoirs in the substrate for retaining a first plurality of compounds. The second carrier includes a second substrate and a plurality of projections, each projection having a distal end provided with a receiving feature for receiving a component from the plurality of reservoirs when the first carrier and the second carrier are coupled.

2003014, Jul 31, 2003

Jan 23, 2003

10/351163

Shiping Chen - Fremont CA, US
Yuling Luo - Castro Valley CA, US

C12M001/34
B05D003/00

435/287200, 427/002110

Disclosed is a microarray printing system and methods of printing probe microarrays. The system has a print head formed of one or more bundles of individual capillaries, such as light-guiding capillaries. The bundles may especially be random bundles of capillaries that provide a large number of probes on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.