Srinivas Iyer - Los Alamos NM,
Andrew M. Dattelbaum - Los Alamos NM,
The Regents of the University of California - Los Alamos NM
250340, 2503411, 2503412, 2503413, 2503414, 2503415, 2503416, 2503417, 2503418, 4283126, 4283122, 4283044, 4283139, 4283179, 428119, 4281951, 428469, 428689, 4284111, 4284256, 428426, 428433, 428457, 428446, 4282921, 4282937, 4282944, 4282947
Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as Cand tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.