Steven S Rothman, Age 794961 Main St APT 307, Tacoma, WA 98407

8591562, Nov 26, 2013

Dec 2, 2009

12/629863

Raimondo D'Ambrosio - Seattle WA, US
Matthew Smyth - Frontenac MO, US
Steven Mark Rothman - Clayton MO, US
John W. Miller - Bellevue WA, US
Jason Fender - Bonney Lake WA, US

University of Washington - Seattle WA
Regents of the University of Minnesota - Saint Paul MN
Washington University in St. Louis - St. Louis MO

A61F 7/12

607113, 607 45

A device for cooling the central nervous system (e. g. , the brain) is disclosed that is specifically designed to provide cooling of an injured central nervous system for neuroprotective, antiepileptogenic, and/or antiepileptic treatments. In one embodiment, a portion of the cooling device is placed in a recess formed by removal of a portion of a patient's skull. An embedded heat-collecting portion of the cooling device is formed to fit in the location of the formed recess and a thermally conductive material of the heat-collecting portion is placed adjacent the dura mater to provide the desired degree of cooling. A heat-dissipating external plate is in thermal contact with the internal plate, and can be selectively sized according to a specific purpose.

2018001, Jan 18, 2018

Sep 25, 2017

15/714518

- Seattle WA, US
- St. Louis MO, US
John W. Miller - Bellevue WA, US
Jeffrey G. Ojemann - Seattle WA, US
Clifford L. Eastman - Seattle WA, US
Matthew Smyth - Frontenac MO, US
Steven M. Rothman - Clayton MO, US
Jason Fender - Bonney Lake WA, US

A61F 7/12
A61F 7/00

The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.

2017005, Mar 2, 2017

Nov 14, 2016

15/351345

- Seattle WA, US
- St. Louis MO, US
- Minneapolis MN, US
John W. Miller - Bellevue WA, US
Matthew Smyth - Frontenac MO, US
Steven M. Rothman - Clayton MO, US

A61F 7/12
A61F 7/10

Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2 C. has been found effective at inhibiting seizures.