Inventors:
Deborah Zimmerman - Oakland CA, US
Mark Selby - San Francisco CA, US
Mohan Srinivasan - San Jose CA, US
Alasdair Bell - Mountain View CA, US
Sujata Singh - Saratoga CA, US
Richard Theolis - Santa Cruz CA, US
Heidi N. Leblanc - Mountain View CA, US
Kyra D. Zens - San Mateo CA, US
Timothy William Sproul - Livermore CA, US
International Classification:
A61K 39/395
C07K 16/22
A61P 19/08
A61P 35/00
C12N 15/13
C12N 15/63
C12N 5/00
C12P 21/08
US Classification:
4241451, 53038823, 5303873, 5303911, 5303917, 5303913, 536 2353, 4353201, 435325, 435 696, 800 4
Abstract:
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPR1A, BMPR1B, ACTR1, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, BMP4, BMPR1A, BMPR1B, ACTR15 and/or BMPR2.