Todd Cast resumes & CV records
Resumes
Todd K Cast, Age 612625 Autumn Trails Dr, Mishawaka, IN 46544
Todd Cast Phones & Addresses
2625 Autumn Trails Dr, Mishawaka, IN 46544 (574) 254-0307
52161 Woodsedge Dr, Granger, IN 46530 (574) 271-9558
South Bend, IN
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Mentions for Todd K Cast
Publications & IP owners
Us Patents
Use Of Inhibitors Of Color Generation In Chromogenic Assays
US Patent:
5212066, May 18, 1993
Filed:
Nov 14, 1991
Appl. No.:
7/791380
Inventors:
James P. Albarella - Granger IN
Todd K. Cast - South Bend IN
David W. Michaels - Elkhart IN
Wallace G. Strycker - Goshen IN
Todd K. Cast - South Bend IN
David W. Michaels - Elkhart IN
Wallace G. Strycker - Goshen IN
Assignee:
Miles Inc. - Elkhart IN
International Classification:
C12Q 154
C12Q 128
C12Q 128
US Classification:
435 28
Abstract:
Disclosed is a novel diagnostic reagent system for the detection of hydroperoxides or substances which react with peroxidatively active substances resulting in the liberation of hydroperoxides which reagent system comprises a chromogenic oxidation indicator and a peroxidase or a peroxidatively active substance, together with an inhibitor of color generation selected from the group of 1,4-disubstituted semicarbazides, thiosemicarbazides and 1,5-disubstituted carbazides as inhibitors of color generation. By inhibiting the generation of color formed by oxidation of the chromogenic indicator, the indicator's usefulness in discriminating between varying concentrations of analyte is enhanced.
Method For The Detection Of Creatinine
US Patent:
6001656, Dec 14, 1999
Filed:
Sep 28, 1998
Appl. No.:
9/161768
Inventors:
Todd K. Cast - Granger IN
Michael J. Pugia - Granger IN
Michael J. Pugia - Granger IN
Assignee:
Bayer Corporation - Elkhart IN
International Classification:
G01N 3370
US Classification:
436 98
Abstract:
Disclosed is an improvement to the assay for creatinine in fluid test samples by contacting the test sample with a reagent formulation containing cupric ions, a hydroperoxide and an oxidizable dye. The improvement involves the inclusion of one or more selected quinolines in the reagent formulation. When the quinoline is substituted with methyl in the 2-5 position and/or a methoxy in the 2-6 position auto-oxidation of the oxidizable dye is reduced. When the quinoline is further substituted in an otherwise unsubstituted carbon atom in the 2-8 position, the assay's resistance to interference from hemoglobin and ascorbate is increased.
Method For The Prevention Of Hemoglobin Interference In Reagent Systems For Measuring Peroxidase Activity
US Patent:
6074881, Jun 13, 2000
Filed:
Aug 3, 1998
Appl. No.:
9/128009
Inventors:
Todd K. Cast - Granger IN
Michael J. Pugia - Granger IN
Michael J. Pugia - Granger IN
Assignee:
Bayer Corporation - Elkhart IN
International Classification:
G01N 3348
G01N 33493
G01N 3370
C12Q 128
G01N 33493
G01N 3370
C12Q 128
US Classification:
436 74
Abstract:
The present invention involves an improvement to an assay for the activity of a metal chelate, such as copper II/creatinine, which activity is related to the concentration of the analyte in a fluid test sample. In carrying out the assay, there is combined the fluid test sample, the metal chelate or precursors thereof, a hydroperoxide, an oxidizable indicator and a pyrazole derivative which inhibits the ability of hemoglobin to oxidize the oxidizable dye.
Total Protein Detection Method
US Patent:
5908787, Jun 1, 1999
Filed:
Sep 23, 1997
Appl. No.:
8/935977
Inventors:
Todd K. Cast - Granger IN
Michael J. Pugia - Granger IN
Michael J. Pugia - Granger IN
Assignee:
Bayer Corporation - Elkhart IN
International Classification:
G01N 3348
US Classification:
436 86
Abstract:
Disclosed is an improved assay for the determination of total protein in an aqueous test fluid such as urine. The assay involves combining the test fluid with a molybdate or tungstate salt and a dye which forms a complex with molybdate or tungstate ion at a pH of 1. 0 to 3. 0 to shift the absorption band of the complex in the presence of protein. There is introduced into the assay a substituted phenolsulfonephthalein dye having a pKa which enables it to operate at a pH of from about 1. 0 to 3. 0 and whose affinity for protein is such that it will provide a detectable response only in the presence of greater than 50 mg/dL of protein to increase the scope of the assay.
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