Victor M Nizet, Age 6113167 Sunstone Pt, San Diego, CA 92130

8148352, Apr 3, 2012

May 11, 2007

12/299934

Victor Nizet - San Diego CA, US
George Y. Liu - Irvine CA, US
Eric Oldfield - Urbana IL, US
Yongcheng Song - Pearland TX, US

The Regents of the University of California - Oakland CA

A61K 31/67
A61K 9/00
A61K 9/70
A61K 9/127
A61K 9/48
A61K 9/20
A61K 9/14
A01N 25/00
A01N 25/08

514 95, 424400, 424405, 424409, 424443, 424450, 424451, 424464, 424489

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the pigment is a virulence factor and potential novel target for antimicrobial therapy.

8507551, Aug 13, 2013

Apr 17, 2006

11/918584

Victor Nizet - San Diego CA, US
George Y. Liu - Irvine CA, US

The Regents of the University of California - Oakland CA

A61K 31/357
A61K 31/216
A61K 31/135
C12Q 1/02

514464, 514534, 514646, 435 29

The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the pigment is a virulence factor and potential novel target for antimicrobial therapy.

2008021, Sep 4, 2008

Feb 3, 2006

11/883692

Randall S. Johnson - San Diego CA, US
Carole Peyssonnaux - Antony, FR
Victor Nizet - San Diego CA, US
Emmanuel Theodorakis - San Diego CA, US

A61K 36/00
C12Q 1/20

424725, 435 29

A method is provided for treating subjects, including humans, with infection or virulence by pathogens. The method involves administering an agent in amounts effective to eradicate or reduce infections and/or an inflammatory response caused by pathogens. Methods for identifying compounds useful as anti-infectives that decrease the immune resistance, virulence, or growth of microbes are also provided. More particularly, there are provided methods for identifying compounds which increase accumulation or stability or activity, or alternatively decrease the degradation of HIF-1a protein.

2009016, Jun 25, 2009

Feb 17, 2006

11/884600

John T. Buchanan - San Diego CA, US
Jason A. Stannard - San Diego CA, US
Xavier Lauth - San Diego CA, US
Vaughn E. Ostland - La Quinta CA, US
Mark E. Westerman - San Diego CA, US
Victor Nizet - San Diego CA, US

A61K 39/09
C12N 1/20
C12N 1/21
C07H 21/04
C07K 14/315
C12Q 1/68
C40B 40/02

4242441, 4352534, 4352523, 536 237, 536 2433, 530350, 435 6, 506 14

The present invention relates generally to the identification of virulence factors from . Specifically, the present invention relates to the identification, characterization and sequencing of a gene for phosphoglucomutase gene, and to a live attenuated strain of deficient in phosphoglucomutase useful as a vaccine in aquatic species, such as fish.

2010016, Jul 1, 2010

Feb 20, 2008

12/528074

Richard L. Gallo - San Diego CA, US
Victor Nizet - San Diego CA, US
Anna Cogen - Silverdale WA, US
YuPing Lai - San Diego CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

A61K 38/16
A01N 37/18
A61K 35/00
A61K 35/74
A61K 38/12
A01P 1/00
A61P 31/04
A61P 17/00
A61P 31/10
A61P 33/00
A61P 31/12
A61P 17/02
A61P 29/00

424 932, 514 12, 514 11, 424 9342, 424780

The disclosure provides methods and compositions useful for treating microbial and viral infections. In certain aspects, the compositions and methods relate to the use of an effective amount of a delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof. In other aspects, the compositions and methods relate to the use of an effective amount of or an extract of 5. epidermidis comprising delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof.

7173007, Feb 6, 2007

Mar 31, 2004

10/815562

Mohamed Zaiou - Saulxures-les-Nancy, FR
Richard L. Gallo - San Diego CA, US
Victor Nizet - San Diego CA, US

The Regents of the University of California - California
The United States of America as represented by the Department of Veteran Affairs - Washington DC

A61K 38/00

514 12, 514 2, 530300, 530350, 435440, 435 691

The disclosure provides a novel class of cationic cathelin-like peptides and polypeptides that have antimicrobial activity. These peptides are useful for inhibiting microbial infection or growth.

2023004, Feb 16, 2023

Dec 14, 2020

17/783255

- Oakland CA, US
Victor Nizet - La Jolla CA, US
Jonathan Andres Valderrama - La Jolla CA, US
Surashree Kulkarni - La Jolla CA, US

C12N 15/10
C12N 15/70
C12N 15/82

CRISPR-based gene-drive system for inhibiting antibiotic resistance of bacteria, including that efficiently copies a gRNA cassette and adjacent cargo that are flanked with sequences homologous to the targeted gRNA/Cas9 cleavage site. This “pro-active” genetic system (Pro-AG) functionally inactivates an antibiotic resistance marker on a high copy number plasmid with greater efficiency than control CRISPR-based methods. Pro-AG can effectively edit large plasmids or single-copy genomic targets, or introduce functional genes, with numerous applications to biotechnology and biomedicine.

2020016, May 28, 2020

Jul 20, 2018

16/632303

- Oakland CA, US
Victor Nizet - San Diego CA, US
Monika Kumaraswamy - San Diego CA, US
Sean Collignon - San Diego CA, US
Gopesh Tilvawala - San Diego CA, US
William Connacher - San Diego CA, US

B05B 17/06
B06B 1/02
B06B 1/06

Articles of manufacture, including an apparatus for acoustic wave based atomization, are provided. The apparatus may include a monocrystalline piezoelectric substrate. The monocrystalline piezoelectric substrate may include a surface patterned with at least one wetting region. The monocrystalline piezoelectric substrate may be configured to respond to an electric signal by at least generating acoustic waves including, for example, surface acoustic waves, Bluestein-Gulayev waves, Lamb waves, Love waves, flexural waves, thickness mode vibrations, mixed-mode waves, longitudinal waves, shear mode vibrations, and/or bulk wave vibrations. The acoustic waves may atomizing at least a portion of a material collected within the at least one wetting region to form a mist of the material. Methods for acoustic wave based atomization are also provided.