William L Demaio Deceased43 Neeld Ln, Chester, PA 19014

William Demaio Phones & Addresses

43 Neeld Ln, Aston, PA 19014 (610) 497-3917

Brookhaven, PA

4 Andover Ct, New Castle, DE 19720

Norwood, PA

Social networks

William L Demaio

Linkedin

Work

Company: Ricerca biosciences Aug 2010 to 2012 Position: Senior director, dmpk

Education

Degree: Ph.D. School / High School: University of Houston 1983 to 1987 Specialities: Chemistry

Skills

LC-MS • Bioanalysis • HPLC • Drug Metabolism • Mass Spectrometry • GLP • GC/MS • Quantitative Analysis • Drug Discovery • Hazardous Materials • SLA • Chromatography • Pharmacokinetics • DMPK • Sample Preparation • Validation • ADME • Analytical Chemistry • UV-Vis

Awards

Dihydrobenzofuran derivatives and uses thereof (SCA-719 metabolites). Gary Paul Stack, Jianyao Wang, William DeMaio, Ronald Jordan, John Chuck Lem Erve, Rasmy Elsayed Talaat, Matthew John Hoffmann. US Patent 7,402,687 issued July, 22, 2008. • Glucuronide metabolites and epimers thereof of tigecycline. Ronald A. Jordan, William DeMaio, Matthew Hoffmann. US Patent 7,534,766 issued May, 19, 2009.

Interests

Perkiomen Township Planning Commission 2006-present, currently serving as Chaiman. Preparation of comprehensive plans and open space plans. Review land development plans for compliance with the Subdivision and Land Development Ordinance (SALDO) and Zoning Code, including evaluation of any requests for waivers. Ensure that applicants provide all relevant information necessary to plans and waiver requests. Originate revisions to the Zoning Code. Provide advice and recommendations to the Township Board of Supervisors on related issues. Collaborate with a diverse professional staff (e.g. engineer, solicitor, code enforcement officer, township manager, county planning staff) and elected officials. Serve as the Township Planning Representative to the Central Perkiomen Valley Regional Planning Commission.

Industries

Pharmaceuticals

Mentions for William L Demaio

Resumes

Resumes

William Demaio Photo 1

Senior Director, Dmpk At Ricerca Biosciences

Position:
Senior Director, DMPK at Ricerca Biosciences
Location:
Cleveland, Ohio
Industry:
Pharmaceuticals
Work:
Ricerca Biosciences since Aug 2010
Senior Director, DMPK
RET Consultants Apr 2010 - Aug 2010
Scientific Advisor
Wyeth Research - Collegeville PA, Princeton NJ and Pearl River NY Feb 1988 - Apr 2010
Associate Director / Principal Research Scientist
Wyeth Research Feb 1988 - Oct 2009
Principal Research Scientist
American Cyanamid - Lederle Laboratories 1988 - 1995
Research Scientist
University of Houston 1983 - 1987
Student
Education:
University of Houston 1983 - 1987
Ph.D., Chemistry
Penn State University 1979 - 1983
BS, Chemistry
Greensburg Central Catholic HS 1975 - 1979
Skills:
LC-MS, Bioanalysis, HPLC, Drug Metabolism, Mass Spectrometry, GLP, GC/MS, Quantitative Analysis, Drug Discovery, Hazardous Materials, SLA, Chromatography, Pharmacokinetics, DMPK, Sample Preparation, Validation, ADME, Analytical Chemistry, UV-Vis
Interests:
Perkiomen Township Planning Commission 2006-present, currently serving as Chaiman. Preparation of comprehensive plans and open space plans. Review land development plans for compliance with the Subdivision and Land Development Ordinance (SALDO) and Zoning Code, including evaluation of any requests for waivers. Ensure that applicants provide all relevant information necessary to plans and waiver requests. Originate revisions to the Zoning Code. Provide advice and recommendations to the Township Board of Supervisors on related issues. Collaborate with a diverse professional staff (e.g. engineer, solicitor, code enforcement officer, township manager, county planning staff) and elected officials. Serve as the Township Planning Representative to the Central Perkiomen Valley Regional Planning Commission.
Honor & Awards:
Dihydrobenzofuran derivatives and uses thereof (SCA-719 metabolites). Gary Paul Stack, Jianyao Wang, William DeMaio, Ronald Jordan, John Chuck Lem Erve, Rasmy Elsayed Talaat, Matthew John Hoffmann. US Patent 7,402,687 issued July, 22, 2008. Glucuronide metabolites and epimers thereof of tigecycline. Ronald A. Jordan, William DeMaio, Matthew Hoffmann. US Patent 7,534,766 issued May, 19, 2009.

Business Records

Name / TitleCompany / ClassificationPhones & Addresses
William Demaio
Information Technology Manager
Pershing LLC 760 Moore Rd, Norristown, PA 19406

Publications

Us Patents

Glucuronide Metabolites And Epimers Thereof Of Tigecycline

US Patent:
7534766, May 19, 2009
Filed:
Nov 2, 2005
Appl. No.:
11/265790
Inventors:
Ronald A. Jordan - Richboro PA,
William DeMaio - Collegeville PA,
Matthew Hoffmann - Pottstown PA,
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/70
C07H 15/24
C07H 1/00
US Classification:
514 23, 536 64, 536124
Abstract:
A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.

Tanaproget Derivatives, Metabolites, And Uses Thereof

US Patent:
7569679, Aug 4, 2009
Filed:
Aug 11, 2005
Appl. No.:
11/201696
Inventors:
Li Shen - Audubon PA,
Kelly Keating - Broomall PA,
Oliver McConnell - Collegeville PA,
William DeMaio - Collegeville PA,
Appavu Chandrasekaran - Plainsboro PA,
Assignee:
Wyeth - Madison NJ
International Classification:
C07H 17/00
C07H 1/00
C07H 1/06
US Classification:
536 174, 536 186
Abstract:
A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.

Tanaproget Derivatives, Metabolites, And Uses Thereof

US Patent:
8389698, Mar 5, 2013
Filed:
Jun 26, 2009
Appl. No.:
12/492229
Inventors:
Li Shen - Audubon PA,
Kelly Keating - Champaign IL,
Oliver McConnell - Collegeville PA,
William DeMaio - Collegeville PA,
Appavu Chandrasekaran - Plainsboro NJ,
Assignee:
Wyeth LLC - Madison NJ
International Classification:
C07H 17/00
C07H 1/00
C07H 1/06
C07D 265/20
C07D 413/04
A61K 31/7042
A61K 31/536
US Classification:
536 174, 536 186, 544 92, 544 96, 514 24, 514 43, 5142305
Abstract:
A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.

Metabolites Of Certain [1,4]Diazepino[6,7,1-Ij]Quinoline Derivatives And Methods Of Preparation And Use Thereof

US Patent:
2006011, May 25, 2006
Filed:
Nov 4, 2005
Appl. No.:
11/267765
Inventors:
Zeen Tong - Collegeville PA,
Jim Wang - Malvern PA,
William DeMaio - Collegeville PA,
Alvin Bach - Riverton NJ,
Ronald Jordan - Richboro PA,
Youchu Wang - Sainte-Anne-de-Bellevue,
P. Sivaramakrishnan Ramamoorthy - Plainsboro NJ,
Gary Stack - Ambler PA,
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/7052
C07H 19/00
C07H 19/22
C07H 17/02
US Classification:
514023000, 514043000, 536017400, 536027100
Abstract:
The invention relates to metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.

Dihydrobenzofuran Derivatives And Uses Thereof

US Patent:
2006024, Oct 26, 2006
Filed:
Apr 21, 2006
Appl. No.:
11/409479
Inventors:
Gary Stack - Ambler PA,
Christine Huselton - Royersford PA,
Jianyao Wang - Monmouth Junction NJ,
William Demaio - Collegeville PA,
Ronald Jordan - Richboro PA,
John Erve - Eagleville PA,
Rasmy Talaat - West Chester PA,
Matthew Hoffmann - Pottstown PA,
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/34
A61K 31/343
C07D 307/02
US Classification:
514469000, 549467000
Abstract:
Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R, R, R, R, R, R, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.

Isolated Hydroxy And N-Oxide Metabolites And Derivatives Of O-Desmethylvenlafaxine And Methods Of Treatment

US Patent:
2008026, Oct 23, 2008
Filed:
Oct 24, 2007
Appl. No.:
11/976413
Inventors:
Matthew J. Hoffmann - Pottstown PA,
William DeMaio - Collegeville PA,
Jim Wang - Malvern PA,
John W. Ullrich - Downingtwon PA,
International Classification:
A61K 31/7032
A61K 31/138
C07C 215/46
A61K 31/14
C07C 211/63
C07H 15/20
US Classification:
514 25, 564319, 514648, 536 179, 564283, 514643
Abstract:
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.

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