William Strohl resumes & CV records
Resumes
William Strohl
William K Strohl, Age 902568 Millbrook Dr, Emmaus, PA 18049
William Strohl Phones & Addresses
2568 Millbrook Dr, Emmaus, PA 18049 (610) 965-4392 (610) 965-5114
Cooperstown, NY
2568 Millbrook Dr, Emmaus, PA 18049 (610) 334-1870
Work
Position:
Machine Operators, Assemblers, and Inspectors Occupations
Education
Degree:
Associate degree or higher
Mentions for William K Strohl
Publications & IP owners
Us Patents
Anti-Addl Monoclonal Antibody And Use Thereof
US Patent:
7731962, Jun 8, 2010
Filed:
Oct 17, 2006
Appl. No.:
11/581843
Inventors:
Gene Kinney - Collegeville PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 39/395
C07K 16/18
G01N 33/53
C07K 16/18
G01N 33/53
US Classification:
4241331, 5303873, 435 72
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Anti-Addl Antibodies And Uses Thereof
US Patent:
7780963, Aug 24, 2010
Filed:
Oct 21, 2005
Appl. No.:
11/256332
Inventors:
Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Assignee:
Merck & Co., Inc. - Rahway NJ
Northwestern University - Evanston IL
Northwestern University - Evanston IL
International Classification:
A61K 39/395
C07K 16/18
G01N 33/53
C07K 16/18
G01N 33/53
US Classification:
4241331, 5303873, 435 72, 4241411
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.
Anti-Addl Antibodies And Uses Thereof
US Patent:
7811563, Oct 12, 2010
Filed:
Oct 21, 2005
Appl. No.:
11/577426
Inventors:
Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William L Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Lei Chang - Westmont IL, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William L Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Lei Chang - Westmont IL, US
Assignee:
Northwestern University - Evanston IL
Merck & Co., Inc. - Rahway NJ
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 39/395
C07K 16/18
G01N 33/53
C07K 16/18
G01N 33/53
US Classification:
4241331, 5303873, 435 72, 4241411
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Anti-Addl Monoclonal Antibody And Use Thereof
US Patent:
8105593, Jan 31, 2012
Filed:
Jun 4, 2010
Appl. No.:
12/793775
Inventors:
Gene Kinney - Collegeville PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 39/395
C07K 16/18
G01N 33/53
C07K 16/18
G01N 33/53
US Classification:
4241331, 5303873, 5303881, 435 72, 4241411
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Anti-Addl Antibodies And Uses Thereof
US Patent:
8383113, Feb 26, 2013
Filed:
Feb 8, 2012
Appl. No.:
13/368742
Inventors:
Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kristen Viola - Chicago IL, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kristen Viola - Chicago IL, US
Assignee:
Northwestern University - Evanston IL
Merck Sharp & Dohme Corp. - Rahway NJ
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 39/395
C07K 16/18
G01N 33/53
C07K 16/18
G01N 33/53
US Classification:
4241331, 5303873, 5303881, 435 72, 4241411
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Anti-Addl Monoclonal Antibody And Use Thereof
US Patent:
8420093, Apr 16, 2013
Filed:
Jan 30, 2012
Appl. No.:
13/361143
Inventors:
Gene Kinney - Collegeville PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
William R. Strohl - Bridgewater NJ, US
Zhiqiang An - Ambler PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 39/395
US Classification:
4241721, 435 792, 435 71, 435 72, 435375, 436501, 4241331, 4241411
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Chimeric Antigen Receptors Comprising Bcma-Specific Fibronectin Type Iii Domains And Uses Thereof
US Patent:
2019033, Oct 31, 2019
Filed:
Sep 11, 2017
Appl. No.:
16/323121
Inventors:
- Horsham PA, US
John Lee - North Wales PA, US
Timothy McCabe - Doylestown PA, US
Jill Mooney - San Diego CA, US
Michael Naso - Swarthmore PA, US
William Strohl - Bridgewater NJ, US
John Lee - North Wales PA, US
Timothy McCabe - Doylestown PA, US
Jill Mooney - San Diego CA, US
Michael Naso - Swarthmore PA, US
William Strohl - Bridgewater NJ, US
Assignee:
Janssen Biotech, Inc. - Horsham PA
International Classification:
C07K 16/28
C12N 15/82
C12N 15/82
Abstract:
BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.
Compositions And Methods For Phagocyte Delivery Of Anti-Staphylococcal Agents
US Patent:
2017023, Aug 17, 2017
Filed:
May 2, 2017
Appl. No.:
15/584235
Inventors:
- New York NY, US
- Horsham PA, US
Anthony LYNCH - Spring House PA, US
William STROHL - Spring House PA, US
Brian WHITAKER - Spring House PA, US
Mark CHIU - Spring House PA, US
Peter T. BUCKLEY - Spring House PA, US
Keri DORN - Spring House PA, US
Michelle KINDER - Spring House PA, US
- Horsham PA, US
Anthony LYNCH - Spring House PA, US
William STROHL - Spring House PA, US
Brian WHITAKER - Spring House PA, US
Mark CHIU - Spring House PA, US
Peter T. BUCKLEY - Spring House PA, US
Keri DORN - Spring House PA, US
Michelle KINDER - Spring House PA, US
International Classification:
C07K 16/12
C07K 14/78
C07K 14/78
Abstract:
The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a infection, including methicillin-resistant
Isbn (Books And Publications)
Lippincott'S Illustrated Reviews: Microbiology
Author:
William A. Strohl
ISBN #:
0397515685
Microbial Chemoautotrophy
Author:
William R. Strohl
ISBN #:
0814203426
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