Zhao Yong Wang, Age 9045 High Ridge Holw, Avon, CT 06001

2012007, Mar 29, 2012

Aug 2, 2011

13/196845

Andrew Rollins - Highland Hts OH, US
David Wilson - Clev. Hts. OH, US
Marco Costa - Pepper Pike OH, US
Hiram Bezerra - Shaker Heights OH, US
Zhao Wang - Cleveland OH, US

CASE WESTERN RESERVE UNIVERSITY - Cleveland OH

G01B 9/02
G06K 9/00

356479, 382131

A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.