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Zhong G Zhao, Age 84Bellevue, WA

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Known as:
Zhongguo G Zhao Zhongguo Z Zhao Zhao Zhongguo Guo Zhao Zhong
Related to:
Cindy Chea 59

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Bellevue, WA

Redmond, WA

Waltham, MA

Ellenville, NY

Brighton, MA

Kiona, WA

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Publications & IP owners

Us Patents

Pyrrolidine Derivatives As Prostaglandin Modulators

US Patent:
7335680, Feb 26, 2008
Filed:
Dec 19, 2002
Appl. No.:
10/499346
Inventors:
Yihua Liao - Westwood MA, US
Zhong Zhao - Wayland MA, US
Gian Luca Araldi - Plymouth MA, US
Assignee:
Laboratoires Serono SA - Vaud
International Classification:
A61K 31/40
C07D 207/10
C07D 207/08
US Classification:
514428, 548572, 548571
Abstract:
Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

Pyrrolidine Derivatives As Prostaglandin Modulators

US Patent:
7635713, Dec 22, 2009
Filed:
Nov 21, 2007
Appl. No.:
11/943684
Inventors:
Yihua Liao - Westwood MA, US
Zhong Zhao - Wayland MA, US
Gian Luca Araldi - Plymouth MA, US
Assignee:
Laboratoires Serono SA - Coinsins
International Classification:
A61K 31/40
C07D 207/08
US Classification:
514424, 548556
Abstract:
Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

Pyrrolidine Derivatives As Prostaglandin Modulators

US Patent:
8058305, Nov 15, 2011
Filed:
Aug 3, 2009
Appl. No.:
12/534292
Inventors:
Yihua Liao - Westwood MA, US
Zhong Zhao - Wayland MA, US
Gian Luca Araldi - Plymouth MA, US
Assignee:
Merck Serono SA - Coinsins
International Classification:
A61K 31/40
C07D 207/06
US Classification:
514424, 548556
Abstract:
Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

Antiproliferative Pyrimidyl, Fused Pyrimidyl And Pyrimidyl Hydrazones

US Patent:
8288398, Oct 16, 2012
Filed:
Dec 8, 2006
Appl. No.:
12/096110
Inventors:
Brian Healey - Scituate MA, US
Zhong Zhao - Wayland MA, US
Amanda Sutton - Hingham MA, US
Matthias Schwarz - Gland, CH
Assignee:
Merck Serono SA - Coinsins, Vaud
International Classification:
A01N 43/54
A61K 31/517
US Classification:
5142664, 544293
Abstract:
The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.

Antiproliferative Pyrimidyl, Fused Pyrimidyl And Pyrimidyl Hydrazones

US Patent:
2012023, Sep 20, 2012
Filed:
May 31, 2012
Appl. No.:
13/484329
Inventors:
BRIAN HEALEY - Scituate MA, US
Zhong Zhao - Wayland MA, US
Amanda Sutton - Hingham MA, US
Matthias Schwarz - Gland (VD), CH
Assignee:
MERCK SERONO SA - Coinsins, Vaud
International Classification:
A61K 31/505
A61K 31/517
C07D 239/42
C07D 413/04
C12N 5/09
C07D 239/47
C07D 413/10
A61K 31/5377
C07D 401/04
A61P 35/00
C07D 239/94
A61K 31/506
US Classification:
5142358, 544293, 5142664, 544326, 514256, 544328, 544317, 514274, 544327, 544329, 544122, 435375
Abstract:
The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.

Glucosylceramide Synthase Inhibitors

US Patent:
2021026, Aug 26, 2021
Filed:
Apr 27, 2021
Appl. No.:
17/242016
Inventors:
- Cambridge MA, US
Cassandra CELATKA - Hull MA, US
Seng CHENG - Natick MA, US
Mary A. CROMWELL - Groton MA, US
Andrew GOOD - Wallingford CT, US
Bradford HIRTH - Framingham MA, US
Katherine JANCSICS - Wilmington MA, US
John P. LEONARD - Manchester NH, US
Lingyun LI - Waltham MA, US
James LILLIE - Wellesley MA, US
Hanlan LIU - Lexington MA, US
Elina MAKINO - Winchester MA, US
John MARSHALL - Hopedale MA, US
Paul MASON - Natick MA, US
Markus METZ - Waltham MA, US
Fazeela MORSHED - Waltham MA, US
Thomas O'SHEA - Wellesley MA, US
Ronald SCHEULE - Hopkinton MA, US
Renato SKERLJ - West Newton MA, US
Bing WANG - Newton MA, US
Yibin XIANG - Dracut MA, US
Zhong ZHAO - Wayland MA, US
Assignee:
GENZYME CORPORATION - Cambridge MA
International Classification:
C07D 487/08
A61K 31/439
A61K 31/454
A61K 38/47
C07D 453/02
C07D 453/00
A61K 31/46
A61K 31/506
A61K 31/551
C07D 455/02
Abstract:
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Glucosylceramide Synthase Inhibitors

US Patent:
2020004, Feb 13, 2020
Filed:
Aug 15, 2019
Appl. No.:
16/542166
Inventors:
- Cambridge MA, US
Cassandra CELATKA - Hull MA, US
Seng CHENG - Natick MA, US
Mary A. CROMWELL - Groton MA, US
Andrew GOOD - Wallingford CT, US
Bradford HIRTH - Framingham MA, US
Katherine JANCSICS - Wilmington MA, US
John P. LEONARD - Manchester NH, US
Lingyun LI - Waltham MA, US
James LILLIE - Wellesley MA, US
Hanlan LIU - Lexington MA, US
Elina MAKINO - Winchester MA, US
John MARSHALL - Hopedale MA, US
Paul MASON - Natick MA, US
Markus METZ - Waltham MA, US
Fazeela MORSHED - Waltham MA, US
Thomas O'SHEA - Wellesley MA, US
Ronald SCHEULE - Hopkinton MA, US
Renato SKERLJ - West Newton MA, US
Bing WANG - Newton MA, US
Yibin XIANG - Dracut MA, US
Zhong ZHAO - Wayland MA, US
International Classification:
C07D 487/08
A61K 31/439
A61K 31/454
A61K 38/47
C07D 453/02
C07D 453/00
A61K 31/46
A61K 31/506
A61K 31/551
C07D 455/02
Abstract:
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Nampt Inhibitors For Cancer Therapy

US Patent:
2018031, Nov 1, 2018
Filed:
Jul 3, 2018
Appl. No.:
16/026901
Inventors:
- Cambridge MA, US
Kara Carter - Cambridge MA, US
Alexandra Joseph - Lexington MA, US
Yiding Hu - Lexington MA, US
Jill Gregory - Acton MA, US
Zhong Zhao - Wayland MA, US
Christopher Yee - Needham MA, US
Mohamud Mohamud - Columbia Heights MN, US
Yibin Xiang - Dracut MA, US
Sanjay Danthi - Roxbury MA, US
Yinyin Huang - Chestnut Hill MA, US
Andrew Papoulis - Canton MA, US
International Classification:
C07D 498/10
G01N 33/60
G01N 33/50
C07D 491/107
C07D 491/20
C12N 5/0781
Abstract:
The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and assays.

Isbn (Books And Publications)

Untersuchungen Uber Zusammenhange Zwischen Chemischen Eigenschaften Von Waldboden Und Buchenmykorrhizen Im Wienerwald

Author:
Zhong Zhao
ISBN #:
3853697690

Possible Relatives

Diana D Zhao  Elizabeth Z Zhao  Feng X Zhao  Gang G Zhao  Guangjun Z Zhao  Gui J Zhao  Henry Zhao  Zhong Li  Zhong Y Liu  Zhong H Pan 

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