Alexander V Gontcharov, Age 55255 N Washington St UNIT 632, Rockville, MD 20850

7714130, May 11, 2010

Jun 16, 2005

11/154921

Alexander V. Gontcharov - Rivervale NJ, US
Gulnaz Khafizova - West Nyack NY, US
John R. Potoski - West Nyack NY, US
Donna Mary Huryn - Monmouth NJ, US

Wyeth - Madison NJ

C07D 413/00
C07D 417/00
C07D 419/00

544368

Methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists, comprising reacting a compound having Formula I:.

2006008, Apr 27, 2006

Oct 21, 2005

11/255562

Dahui Zhou - East Brunswick NJ, US
Gary Stack - Ambler PA, US
Alexander Gontcharov - Rivervale NJ, US

Wyeth - Madison NJ

C07D 307/87
A61K 31/343
C07F 1/08

514469000, 549467000

This invention concerns a process for the preparation of benzofuran derivatives. In some aspects, these compounds are of formula I: wherein each of R, R, R, and Ris as defined herein.

2006011, May 25, 2006

Oct 21, 2005

11/255645

Alexander Gontcharov - Rivervale NJ, US
Gulnaz Khafizova - West Nyack NY, US
John Potoski - West Nyack NY, US
Qing Yu - Laval, CA
Chia-Cheng Shaw - Montreal, CA
Gary Stack - Ambler PA, US
Dahui Zhou - New Brunswick NJ, US

Wyeth - Madison NJ

A61K 31/343
C07D 307/87
C07F 3/02

514469000, 549467000, 26066500G

The present invention concerns production of a compound of the formula or a pharmaceutically acceptable salt thereof by a process which utilizes the cyclization of a compound of the formula: where Ar, Y, R, R, R, and m are as defined herein.

2007012, Jun 7, 2007

Dec 4, 2006

11/566415

Alexander Gontcharov - Rivervale NJ, US
Antonia Nikitenko - Tarrytown NY, US
Jean Schmid - Chester NY, US
John Potoski - West Nyack NY, US

Wyeth - Madison NJ

A61K 31/495
C07D 241/04

514252120, 544400000

Processes are disclosed for preparing substituted aryl cycloalkanol derivatives, particularly chiral substituted aryl cycloalkanol derivatives of the general formula:

2008003, Feb 14, 2008

Apr 18, 2007

11/787860

Alexander Gontcharov - Rivervale NJ, US
Antonia Nikitenko - Tarrytown NY, US
Panolil Raveendranath - Monroe NY, US
Chia-Cheng Shaw - Ville Saint-Laurent, CA
Bogdan Wilk - New City NY, US
Dahui Zhou - East Brunswick NJ, US

Wyeth - Madison NJ

C07D 311/04

549402000, 549406000, 549407000

Methods of preparing compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R, R, R, R, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

2008005, Feb 28, 2008

Aug 15, 2007

11/893335

Alexander Gontcharov - Rivervale NJ, US
John Potoski - West Nyack NY, US

Wyeth - Madison NJ

C07D 209/04

548465000, 548512000

Processes for dialkylating indolinones, specifically indolin-2-ones are provided. The processes for dialkylating an indolin-2-one include performing the dialkylation in the presence of at least 2 equivalents of a first base, a second base containing at least 1 equivalent of lithium diisopropylamide, and an alkylating agent. Processes for preparing a compound of the structure are provided, wherein R, R, R, R, R, R, and Rare as defined herein. In one embodiment, a process for preparing 5-(4′-fluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-5′-yl)-1-methyl-1H-pyrrole-2-carbonitrile is provided.

2008014, Jun 19, 2008

Aug 22, 2007

11/843364

Anita Wai-Yin Chan - Fort Lee NJ, US
Zhixian Ding - Fort Lee NJ, US
Mousumi Ghosh - Elmwood Park NJ, US
Mahmut Levent - Bloomfield NJ, US
Panolil Raveendranath - Monroe NY, US
Jianxin Ren - Nanuet NY, US
Maotang Zhou - Cedar Knolls NJ, US
Asaf Alimardanov - Nanuet NY, US
Alexander V. Gontcharov - Rivervale NJ, US
Antonia A. Nikitenko - Tarrytown NY, US
John R. Potoski - West Nyack NY, US
Girija Raveendranath - Monroe NY, US
Vijay Raveendranath - Albany NY, US
Sanjay Raveendranath - Monroe NY, US

Wyeth - Madison NJ

C07D 209/34
A61K 31/4015

514418, 548486

Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula:The processes disclosed may be used to prepare, inter alia, 7-fluoro-1-[(S, 2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one and 7-fluoro-1-[(S, 2R)-1-(3,5-difluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one. Intermediates of the processes are also disclosed.

2008031, Dec 25, 2008

May 15, 2008

12/120959

Yanzhong Wu - Bardonia NY, US
Karen Sutherland - New City NY, US
John Leo Considine - Bridgewater NJ, US
Bogdan Kazimierz Wilk - New City NY, US
Pierre Giguere - Laval, CA
Michael MacEwan - Monroe NY, US
Archana Sharma - Congers NY, US
Alexander Gontcharov - Rivervale NJ, US

Wyeth - Madison NJ

C07D 209/96

548411

Processes for preparing substituted oxindole-2-ones, and specifically the following, are described, wherein R-R, R, and n are defined herein. The processes include reacting a first alkali metal hydroxide, a tetraalkyl ammonium salt, a benzonitrile, and RX or XCH(CH)X′, wherein Ris Cto Calkyl, substituted Cto Calkyl, Cto Ccycloalkyl, substituted Cto Ccycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic, X and X′ are, independently, leaving groups, and n is 1 to 5; (ii) reacting the product of step (i) with a second alkali metal hydroxide at a temperature of at least about 60 C.; (iii) reacting the product of step (ii) with an alkali alkoxide at a temperature of at least about 140 C. to form an oxindol-2-one; (iv) brominating the oxindol-2-one; and (v) coupling the brominated oxindol-2-one with a coupling reagent.