Denis E Ryono, Age ~73100 3Rd St, Minneapolis, MN 55401

Denis Ryono Phones & Addresses

100 3Rd St, Minneapolis, MN 55401 (612) 333-3977

Winona, MN

Trenton, NJ

28 Marion Rd, Princeton, NJ 08540 (609) 921-0171

44 Nassau St, Princeton, NJ 08542 (609) 921-0171

100 3Rd Ave S UNIT 1302, Minneapolis, MN 55401 (609) 774-8729

Work

Position: Sales Occupations

Emails

d***o@aol.com

Mentions for Denis E Ryono

Publications

Us Patents

Benzamide Ligands For The Thyroid Receptor

US Patent:
6395784, May 28, 2002
Filed:
May 31, 2001
Appl. No.:
09/871347
Inventors:
Denis E. Ryono - Princeton NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A01N 3712
US Classification:
514563, 514538, 514539, 560 39, 560 41, 562444, 562449, 562450
Abstract:
New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH —, —CO—, or —NH—; R is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R and R are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R and R being other than hydrogen; R is methyl, ethyl, n-propyl or trifluoromethyl; R is hydrogen or lower alkyl; R is carboxylic acid, or esters or prodrugs; R is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Aminoalkyl And Related Substituted Phosphinic Acid Angiotensin Converting Enzyme Inhibitors

US Patent:
4560680, Dec 24, 1985
Filed:
May 10, 1984
Appl. No.:
6/608850
Inventors:
Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 31675
C07F 960
C07F 965
US Classification:
514 82
Abstract:
Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.

S-Acylation Products Of Mercaptoacyl Amino Acids And Carboxyl Group Containing Diuretics

US Patent:
4482725, Nov 13, 1984
Filed:
Apr 3, 1980
Appl. No.:
6/136842
Inventors:
Miguel A. Ondetti - Princeton NJ
Denis E. Ryono - Princeton NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07D20716
US Classification:
548533
Abstract:
The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.

N-Heterocyclic Alcohol Renin Inhibitors

US Patent:
4885292, Dec 5, 1989
Filed:
Jun 29, 1989
Appl. No.:
7/373633
Inventors:
Denis E. Ryono - Princeton NJ
Harold N. Weller - Pennington NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 3155
C07D41312
US Classification:
514211
Abstract:
Compounds of the formula ##STR1## are disclosed wherein R. sub. 1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.

N-Heterocyclic Alcohol Derivatives

US Patent:
4981843, Jan 1, 1991
Filed:
Apr 7, 1988
Appl. No.:
7/178948
Inventors:
Denis E. Ryono - Princeton NJ
Harold N. Weller - Pennington NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 3743
C07K 508
US Classification:
514 18
Abstract:
Compounds of the formula ##STR1## wherein R. sub. 1 is an N-heterocyclic group as defined herein and Y can be --NH--, --O-- or --CH. sub. 2 --, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

Amino Acid Ester Renin Inhibitors

US Patent:
4665193, May 12, 1987
Filed:
Jun 27, 1986
Appl. No.:
6/879693
Inventors:
Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07D23364
US Classification:
548344
Abstract:
Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.

Hypotensive Imidazole Substituted Mercapto-1-Oxopropyl-L-Prolines

US Patent:
4313948, Feb 2, 1982
Filed:
Nov 20, 1980
Appl. No.:
6/208739
Inventors:
Miguel A. Ondetti - Princeton NJ
Denis E. Ryono - Princeton NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 31415
C07D40306
US Classification:
424273R
Abstract:
The invention relates to new compounds useful as hypotensive agents, of the formula: ##STR1## wherein R is hydrogen or lower alkyl; R. sub. 1 is hydrogen, lower alkyl or halo substituted lower alkyl; R. sub. 2 is hydrogen, ##STR2## or ##STR3## R. sub. 3 is lower alkyl, phenyl or phenyl lower alkyl; Pr--COOR is a substituted or unsubstituted proline.

Ureido Renin Inhibitors

US Patent:
4757050, Jul 12, 1988
Filed:
Aug 28, 1987
Appl. No.:
7/093080
Inventors:
Sesha I. Natarajan - Neshanic Station NJ
Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ
Assignee:
E. R. Squibb Sons, Inc. - Princeton NJ
International Classification:
A61K 3702
C07K 702
C07K 508
C07K 510
C07K 706
US Classification:
514 18
Abstract:
Compounds of the formula ##STR1## are disclosed. These compounds intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.

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