Denis E Ryono, Age 74100 3Rd St, Minneapolis, MN 55401

Denis Ryono Phones & Addresses

100 3Rd St, Minneapolis, MN 55401 (612) 333-3977

Winona, MN

Trenton, NJ

28 Marion Rd, Princeton, NJ 08540 (609) 921-0171

44 Nassau St, Princeton, NJ 08542 (609) 921-0171

100 3Rd Ave S UNIT 1302, Minneapolis, MN 55401 (609) 774-8729

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Denis E Ryono

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Work

Company: Bristol-myers squibb 1977 to 2007 Position: Research fellow

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Pharmaceuticals

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Resumes

Denis Ryono Photo 1

Denis Ryono

Location:
Minneapolis, MN
Industry:
Pharmaceuticals
Work:
Bristol-Myers Squibb 1977 - 2007
Research Fellow

Publications

Us Patents

Benzamide Ligands For The Thyroid Receptor

US Patent:
6395784, May 28, 2002
Filed:
May 31, 2001
Appl. No.:
09/871347
Inventors:
Denis E. Ryono - Princeton NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A01N 3712
US Classification:
514563, 514538, 514539, 560 39, 560 41, 562444, 562449, 562450
Abstract:
New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH —, —CO—, or —NH—; R is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R and R are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R and R being other than hydrogen; R is methyl, ethyl, n-propyl or trifluoromethyl; R is hydrogen or lower alkyl; R is carboxylic acid, or esters or prodrugs; R is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Aniline-Derived Ligands For The Thyroid Receptor

US Patent:
6800605, Oct 5, 2004
Filed:
Jan 16, 2001
Appl. No.:
09/761050
Inventors:
Todd J. Friends - Hamilton NJ
Denis E. Ryono - Princeton NJ
Minsheng Zhang - Warren NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07C 3700
US Classification:
514 2, 514576, 514577, 514717, 514730, 514736, 568579, 568583, 568585, 568588, 568626, 568630, 568635
Abstract:
New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH —, —CO—, or —NH—; Y is —(CH ) — where n is an integer from 1 to 5, or cis- or trans-ethylene; R is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R and R are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R and R being other than hydrogen; R is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is carboxylic acid, or esters or prodrugs; R is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Thyroid Receptor Ligands And Method Ii

US Patent:
6989402, Jan 24, 2006
Filed:
Dec 23, 1999
Appl. No.:
09/868889
Inventors:
Jon Hangeland - Morrisville PA, US
Minsheng Zhang - Warren NJ, US
Yolanda Caringal - Lawrenceville NJ, US
Denis Ryono - Princeton NJ, US
Yi-Lin Li - Huddinge, SE
Johan Malm - Skogas, SE
Ye Liu - Tullinge, SE
Neeraj Garg - Tumba, SE
Chris Litten - Tumba, SE
Ana Maria Garcia Collazo - Stockholm, SE
Konrad Koehler - Huddinge, SE
Assignee:
Karo Bio AB - Huddinge
International Classification:
A61K 31/44
A61K 31/192
A61K 31/40
A61K 31/4174
C07D 211/56
C07D 213/72
C07D 229/38
C07D 265/30
C07D 241/04
C07D 207/14
US Classification:
514563, 5142378, 514398, 514399, 544162, 544402, 546224, 546309, 5483714, 548567, 562444, 562449
Abstract:
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; Ris halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; Rand Rare the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, at least one of Rand Rbeing other than hydrogen; Ris a carboxylic acid amide (CONR′R″) or an acylsulphonamide (CONHSO2R′) derivative, or a pharmaceutically acceptable salt thereof, and all stereoisomers thereof; or when n is equal to or greater than one, Rmay be a heteroaromatic moiety which may be substituted or unsubstituted, or an amine (NR′R″). Ris hydrogen or an acyl (such as acetyl or benzoyl) or other group capable of bioconversion to generate the free phenol structure (wherein R=H). In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a Tregulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Aniline-Derived Ligands For The Thyroid Receptor

US Patent:
7109164, Sep 19, 2006
Filed:
Aug 30, 2004
Appl. No.:
10/930360
Inventors:
Todd J. Friends - Hamilton NJ, US
Denis E. Ryono - Princeton NJ, US
Minsheng Zhang - Warren NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07C 37/00
US Classification:
514 2, 514576, 514577, 514717, 514730, 514736, 568579, 568583, 568585, 568588, 568626, 568630, 568635
Abstract:
New thyroid receptor ligands are provided which have the general formulaIn addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a Tregulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Benzamide Derivatives As Thyroid Receptor Ligands

US Patent:
7153997, Dec 26, 2006
Filed:
Jul 8, 2003
Appl. No.:
10/520902
Inventors:
Neeraj Garg - Tumba, SE
Mahmoud Rahimi Ghadim - Stockholm, SE
Thomas Anders Wilson Ericsson - Sodertawg, SE
Lars Johan Malm - Trangsund, SE
Denis Evan Ryono - Princeton NJ, US
Assignee:
Karo Bio AB - Huddinge
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07C 229/08
A61K 31/195
US Classification:
562444, 562442, 562443, 562445, 562447, 514563
Abstract:
This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described herein is administered in a therapeutically effective amount.

Thyroid Receptor Ligands And Method Ii

US Patent:
7288571, Oct 30, 2007
Filed:
Jul 26, 2005
Appl. No.:
11/189654
Inventors:
Jon Hangeland - Morrisville PA, US
Minsheng Zhang - Warren NJ, US
Yolanda Caringal - Lawrenceville NJ, US
Denis Ryono - Princeton NJ, US
Yi-Lin Li - Huddinge, SE
Johan Malm - Skogas, SE
Ye Liu - Tullinge, SE
Neeraj Garg - Tumba, SE
Chris Litten - Tumba, SE
Ana Maria Garcia Collazo - Stockholm, SE
Konrad Koehler - Huddinge, SE
Assignee:
Karo Bio AB - Huddinge
International Classification:
A61K 31/18
C07C 311/50
US Classification:
514601, 514649, 564 80, 564336
Abstract:
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; Ris halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; Rand Rare the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, at least one of Rand Rbeing other than hydrogen; Ris a carboxylic acid amide (CONR′R″) or an acylsulphonamide (CONHSOR′) derivative, or a pharmaceutically acceptable salt thereof, and all stereolsom thereof; or when n is equal to or greater than one, Rmay be heteroaromatic moiety which may be substituted or unsubstituted, or an amine (NR′R″). Ris hydrogen or an acyl (such as acetyl or benzoyl) or other group capable of bioconversion to generate the free phenol structure (wherein R—H). In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependant upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a Tregulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Substituted Anilide Ligands For The Thyroid Receptor

US Patent:
7342127, Mar 11, 2008
Filed:
Jan 23, 2004
Appl. No.:
10/763878
Inventors:
William N. Washburn - Titusville NJ, US
Wei Meng - Pennington NJ, US
Denis E. Ryono - Princeton NJ, US
Bruce A. Ellsworth - Princeton NJ, US
Thomas Ericsson - Sodertalje, SE
Mahmoud Rahimi-Ghadim - Stockholm, SE
Neeraj Garg - Tumba, SE
Johan Malm - Trangsund, SE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
Karo Bio AB - Huddinge
International Classification:
C07C 54/00
C07C 315/00
C07C 229/00
A01N 37/12
US Classification:
562471, 562430, 562442, 562443, 514534
Abstract:
Novel thyroid receptor ligands are provided having the general formula IIn addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolic dysfunction or which are dependent upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount.

Thyroid Receptor Ligands

US Patent:
7557143, Jul 7, 2009
Filed:
Apr 15, 2004
Appl. No.:
10/826100
Inventors:
Denis E. Ryono - Princeton NJ, US
Jon J. Hangeland - Morrisville PA, US
Todd J. Friends - Bordentown NJ, US
Tamara Dejneka - Skillman NJ, US
Pratik Devasthale - Plainsboro NJ, US
Yolanda V. Caringal - Lawrenceville NJ, US
Minsheng Zhang - Warren NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Johan Malm - Trangsund, SE
Andrei Sanin - Varby, SE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/165
A61K 31/19
C07C 239/00
C07C 325/00
C07C 229/00
C07C 59/00
US Classification:
514568, 514617, 562426, 562433, 562452, 562465, 564161
Abstract:
Thyroid receptor ligands are provided which have the general formula IIn addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount.

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