Denis E Ryono, Age ~73100 3Rd St, Minneapolis, MN 55401

6395784, May 28, 2002

May 31, 2001

09/871347

Denis E. Ryono - Princeton NJ

Bristol-Myers Squibb Company - Princeton NJ

A01N 3712

514563, 514538, 514539, 560 39, 560 41, 562444, 562449, 562450

New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH —, —CO—, or —NH—; R is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R and R are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R and R being other than hydrogen; R is methyl, ethyl, n-propyl or trifluoromethyl; R is hydrogen or lower alkyl; R is carboxylic acid, or esters or prodrugs; R is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

4560680, Dec 24, 1985

May 10, 1984

6/608850

Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

A61K 31675
C07F 960
C07F 965

514 82

Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.

4482725, Nov 13, 1984

Apr 3, 1980

6/136842

Miguel A. Ondetti - Princeton NJ
Denis E. Ryono - Princeton NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

C07D20716

548533

The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.

4885292, Dec 5, 1989

Jun 29, 1989

7/373633

Denis E. Ryono - Princeton NJ
Harold N. Weller - Pennington NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

A61K 3155
C07D41312

514211

Compounds of the formula ##STR1## are disclosed wherein R. sub. 1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.

4981843, Jan 1, 1991

Apr 7, 1988

7/178948

Denis E. Ryono - Princeton NJ
Harold N. Weller - Pennington NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

A61K 3743
C07K 508

514 18

Compounds of the formula ##STR1## wherein R. sub. 1 is an N-heterocyclic group as defined herein and Y can be --NH--, --O-- or --CH. sub. 2 --, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

4665193, May 12, 1987

Jun 27, 1986

6/879693

Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

C07D23364

548344

Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.

4313948, Feb 2, 1982

Nov 20, 1980

6/208739

Miguel A. Ondetti - Princeton NJ
Denis E. Ryono - Princeton NJ

E. R. Squibb & Sons, Inc. - Princeton NJ

A61K 31415
C07D40306

424273R

The invention relates to new compounds useful as hypotensive agents, of the formula: ##STR1## wherein R is hydrogen or lower alkyl; R. sub. 1 is hydrogen, lower alkyl or halo substituted lower alkyl; R. sub. 2 is hydrogen, ##STR2## or ##STR3## R. sub. 3 is lower alkyl, phenyl or phenyl lower alkyl; Pr--COOR is a substituted or unsubstituted proline.

4757050, Jul 12, 1988

Aug 28, 1987

7/093080

Sesha I. Natarajan - Neshanic Station NJ
Denis E. Ryono - Princeton NJ
Edward W. Petrillo - Pennington NJ

E. R. Squibb Sons, Inc. - Princeton NJ

A61K 3702
C07K 702
C07K 508
C07K 510
C07K 706

514 18

Compounds of the formula ##STR1## are disclosed. These compounds intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.