Inventors:
Denis E. Ryono - Princeton NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A01N 3712
US Classification:
514563, 514538, 514539, 560 39, 560 41, 562444, 562449, 562450
Abstract:
New thyroid receptor ligands are provided which have the general formula in which: X is âOâ, âSâ, âCH â, âCOâ, or âNHâ; R is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R and R are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R and R being other than hydrogen; R is methyl, ethyl, n-propyl or trifluoromethyl; R is hydrogen or lower alkyl; R is carboxylic acid, or esters or prodrugs; R is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.