John Thomas Loffredo, Age 45646 Friar Dr, Yardley, PA 19067

John Loffredo Phones & Addresses

266 Greenview Rd, Morrisville, PA 19067 (215) 493-3780

Yardley, PA

Hazle Township, PA

Princeton Junction, NJ

1706 Norman Way, Madison, WI 53705 (608) 441-6909

75 Grannis St, East Haven, CT 06512 (203) 467-1539 (203) 467-6704

76 Grannis St, East Haven, CT 06512 (203) 466-1071

Buck, PA

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Publications & IP owners

Us Patents

Glypican-3-Binding Fibronectin Based Scaffold Molecules

US Patent:
2020026, Aug 20, 2020
Filed:
Jan 24, 2020
Appl. No.:
16/751788
Inventors:
- Princeton NJ, US
Joseph TOTH - Belmont MA, US
Ginger C. RAKESTRAW - Somerville MA, US
Irvith M. CARVAJAL - Somerville MA, US
Steven R. O'NEIL - Wayland MA, US
Guodong CHEN - East Brunswick NJ, US
Richard Y. HUANG - Bridgewater NJ, US
Bryan C. BARNHART - San Francisco CA, US
John Thomas LOFFREDO - Yardley PA, US
Christina TERRAGNI - Wilmington MA, US
International Classification:
C07K 14/78
A61K 47/64
A61K 47/60
G01N 33/68
Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains (Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 Fn3 drug conjugates are also provided.

Glypican-3-Binding Fibronectin Based Scaffold Molecules

US Patent:
2019007, Mar 14, 2019
Filed:
Sep 22, 2016
Appl. No.:
15/760449
Inventors:
- Princeton NJ, US
Joseph TOTH - Belmont MA, US
Ginger C. RAKESTRAW - Somerville MA, US
Irvith M. CARVAJAL - Somerville MA, US
Steven R. O'NEIL - Wayland MA, US
Guodong CHEN - East Brunswick NJ, US
Richard Y. HUANG - Bridgewater NJ, US
Bryan C. BARNHART - San Francisco CA, US
John Thomas LOFFREDO - Yardley PA, US
Christina TERRAGNI - Wilmington MA, US
International Classification:
C07K 14/78
A61K 47/64
G01N 33/68
Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains (Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 Fn3 drug conjugates are also provided.

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