John R Mccall, Age 421274 Hannibal St, Noblesville, IN 46060

2007011, May 24, 2007

Jul 24, 2006

11/492685

Gary Tollefson - Indianapolis IN, US
Anthony McKinney - San Diego CA, US
Michelle Higgin - Apex NC, US
John McCall - Boca Grande FL, US

A61K 31/485
A61K 31/165

514282000, 514618000

Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a metabolite of naltrexone, such as 6-β-naltrexol or a prodrug of a naltrexone metabolite, and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) and/or a melanocortin 4 receptor (MC4-R), and/or increases the concentration of α-MSH in the central nervous system. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity with a metabolite of naltrexone, such as 6-β-naltrexol or a prodrug of a naltrexone metabolite, and treating that individual to enhance α-MSH activity, e.g., by administration of a second compound causes increased agonism of MC3-R and/or MC4-R, and/or increases the concentration of α-MSH in the central nervous system.