Lai Xu, Age 64Bellefontaine, OH

Lai Xu Phones & Addresses

Bellefontaine, OH

600 S Frederick Ave #32, Gaithersburg, MD 20877 (301) 947-8839

North Potomac, MD

Martinsburg, WV

Brandywine, WV

Brockton, MA

Bethesda, MD

Roxbury, MA

Augusta, GA

12224 Wonder View Way, North Potomac, MD 20878 (301) 947-8839

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Work

Company: Xu lai Address: 78 Mountain Laurel Lane, Abington, MA 02351 Phones: (781) 681-9935 Position: Executive officer Industries: Savings Institutions, Federally Chartered

Mentions for Lai Xu

Lai Xu resumes & CV records

Resumes

Lai Xu Photo 34

Senior Staff Fellow

Location:
Gaithersburg, MD
Industry:
Government Administration
Work:
Fda
Senior Staff Fellow
Lai Xu Photo 35

Lai Xu

Education:
Universität Leipzig
Lai Xu Photo 36

Lai Xu

Publications & IP owners

Us Patents

Oligonucleotides Targeting Human Endogenous Retrovirus 9 (Erv-9) Long Terminal Repeat (Ltr) And Methods Of Use

US Patent:
2011016, Jul 7, 2011
Filed:
Sep 11, 2009
Appl. No.:
13/062858
Inventors:
Lai Xu - North Potomac MD, US
Amy S. Rosenberg - Kensington MD, US
Abdel Elkahloun - Bethesda MD, US
Fabio Candotti - Brookville MD, US
International Classification:
A61K 31/7088
A61P 35/00
C07H 21/02
C12Q 1/68
US Classification:
514 44 A, 536 245, 435 611
Abstract:
Described herein are oligonucleotides that target the human endogenous retrovirus-9 (ERV-9) long terminal repeat (LTR). The ERV-9 LTR oligonucleotides specifically hybridize with either the coding strand or non-coding strand of ERV-9 LTR. It is disclosed herein that ERV-9 LTR oligonucleotides inhibit the proliferation of cancer cells, including breast cancer, liver cancer, prostate cancer, fibrosarcoma and myeloid cancer cells. Also described herein are methods of treating a subject diagnosed with cancer comprising administering to the subject an ERV-9 LTR oligonucleotide. In some examples, the methods further comprise administering a second therapeutic agent, such as an antisense compound or a chemotherapeutic agent.

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