Tomas G Kempe, Age 80997 Santa Cruz Ct, Lusby, MD 20657

6534646, Mar 18, 2003

Jun 4, 2001

09/874161

Tomas Kempe - Washington DC

Barrskogen, Inc. - Washington DC

C07H 2100

536 253, 536 2532, 558192, 560155, 428402

A labeling reagent for use in oligonucleotide (âoligoâ) synthesis, as well as a method of preparing such a labeling reagent, a method of using such a reagent for synthesizing a labeled oligonucleotide, and an oligonucleotide prepared using such a reagent. The reagent can be used to label either the 3â or 5â termini of a synthesized oligo, and/or for one or more positions along the oligo. The labeling reagent can be prepared by a reaction scheme that involves the initial preparation of hydroxyacids, tritylated hydroxyacids and coupling of such derivatives to diamine, wherein the amine function serves at an attachment point for labels and the hydroxyl groups can either be used to immoblize the molecules to support or can be converted to provide a phosphorylating reagent.

6734297, May 11, 2004

Jan 14, 2003

10/341629

Tomas Kempe - Washington DC

Barrskogen, Inc. - Washington DC

C07H 2100

536 253, 536 2532, 536 231, 435 6, 501 33, 526 72, 526336

A labeling reagent for use in oligonucleotide (âoligoâ) synthesis, as well as a method of preparing such a labeling reagent, a method of using such a reagent for synthesizing a labeled oligonucleotide, and an oligonucleotide prepared using such a reagent. The reagent can be used to label either the 3â or 5â termini of a synthesized oligo, and/or for one or more positions along the oligo. The labeling reagent can be prepared by a reaction scheme that involves the initial preparation of hydroxyacids, tritylated hydroxyacids and coupling of such derivatives to diamine, wherein the amine function serves at an attachment point for labels and the hydroxyl groups can either be used to immoblize the molecules to support or can be converted to provide a phosphorylating reagent.

4658014, Apr 14, 1987

Dec 20, 1985

6/811179

Tomas G. Kempe - Minnetonka MN

C07K 736

530307

New peptides are disclosed which have biological activity of the same type as calcitonins and which have been modified with desaminocysteine and. alpha. -aminosuberic acid at the N-terminal and new amino acid substituents at the penultimate position of the C-terminal.

5738829, Apr 14, 1998

Feb 15, 1996

8/602211

Tomas Kempe - Bowie MD

Barrskogen, Inc. - Washington DC

G05D 2300
C08F 200

422107

A process and apparatus for the cleavage and deprotection of newly synthesized oligonucleotides from solid supports, which involves incubating the solid support in an environment comprising gaseous cleavage/deprotection reagent such as gaseous ammonia or ammonium hydroxide vapors. The method lends itself well to the use of supports such as microtiter plates, that can be used to simultaneously perform up to 96 individual synthetic processes.

4652627, Mar 24, 1987

Aug 16, 1985

6/766276

Tomas G. Kempe - Minnetonka MN
Flora Chow - Minnetonka MN

C07K 736
A61K 3724

530307

New calcitonin analogs are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid substituent in at least one of the positions 31 and 32 instead of the natural L-amino acid units. The calcitonin analog may be analogs of salmon, eel, chicken, bovine, porcine, ovine, murine or human calcitonins.

4687839, Aug 18, 1987

Dec 23, 1985

6/812893

Tomas G. Kempe - Minnetonka MN

C07K 710

530324

New calcitonin gene related peptide analogs (CGRP) are disclosed which have biological activity of the same type as known calcitonin gene related peptides and which have a D-amino acid substituent in at least one of the positions 36 and 37 instead of the natural L-amino acids.

5897838, Apr 27, 1999

Mar 11, 1994

8/209786

Tomas Kempe - Bowie MD

Barrskogen, Inc. - Washington DC

G01N 100

422101

A simple, convenient and inexpensive apparatus for the concentration or evaporation of aqueous solutions typically used in biomedical research and development. The apparatus involves the use of a combined vacuum and blow-down effect, optionally including the application of heat. Using the apparatus a vacuum, as can be provided by a common water aspirator, serves the multiple purposes of facilitating the evaporation, creating the blow-down effect, and flushing the evaporated solvent from the system.

5656741, Aug 12, 1997

May 5, 1995

8/435526

Flora Chow - Bowie MD
Tomas Kempe - Bowie MD

Barrskogen, Inc. - Bowie MD

C07H 2100
C07H 2104
C07H 2102
C07H 1900

536 253

Reagents useful for the rapid processing of synthetic oligonucleotides, including a basic reagent for the cleavage and deprotection of the synthesized oligonucleotides from a support, and a precipitating reagent useful for recovering the synthesized oligonucleotide by precipitation from solution. The basic reagent optionally includes a wetting agent useful for the cleavage from lipophilic supports.