Inventors:
John Diener - Cambridge MA, US
Jayaram Srinivasan - Murrysville PA, US
Nobuko Hamaguchi - Framingham MA, US
Jill Blanchard - Arlington MA, US
Jeffrey Kurz - Somerville MA, US
Markus Kurz - Newton MA, US
Sharon Cload - Cambridge MA, US
David Epstein - Belmont MA, US
Charles Wilson - Concord MA, US
Martin Stanton - Stow MA, US
International Classification:
C12Q001/68
C07H021/04
Abstract:
Compositions which recognize and report on the concentration selectively adenosine diphosphate (ADP) and methods of making and using them are provided. The invention further relates to methods of using the compositions to monitor function of biological agents. Reagents and systems for performing the methods are also provided. The methods of the invention are useful in diagnostic applications and drug optimization.